Resolvin D1 altered the cytotoxicity of P. gingivalis supernatant on HGFs. Resolvin D1 significantly reduced GRO, marginally reduced MCP-1, and marginally increased TGF-β1 from P. gingivalis-treated HGFs, which could alter the ability of P. gingivalis to induce inflammation.

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Aims and objectives: The aim of this study was to assess the influence of periodontal status on quality of life (QoL) with the use of a short version of the Oral Health Impact Profile (OHIP-14) in patients with periodontal disease attending university in Riyadh, Saudi Arabia. Materials and methods: Adult patients diagnosed with periodontal disease and having minimum of 15 teeth or more present was included. Included patients were requested to fill a questionnaire form and undergo a comprehensive clinical periodontal examination. The influence of oral health on patients’ QoL was assessed using the Arabic version of OHIP-14. Results: A total of 25 adults aged between 23 and 80 years with a mean age of 49 years completed the questionnaire. The impact of periodontal disease on patient’s QoL was statistically significant in 2 domains, namely physical pain ( P = .004) and psychological disability ( P = .001). The severity of periodontal disease did not show a negative impact on functional limitation. In general, the total OHIP-14 scores were statistically significant with the number of teeth with pocket depths of 5 mm ( P = .001) and 7 mm ( P = .011). Conclusions: Periodontal destruction has a negative impact on QoL. The use of this index as well as other patient-centered outcome measures has significant implications in periodontology, including treatment planning and evaluation of treatment results.