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Background: Adolescence is a crucial period for developing and maintaining social and emotional habit. Multiple factors determine the mental health of an adolescent. This study aimed to examine the associations between smoking and other factors with emotional mental disorders among adolescents. Subjects and Method: This was a cross sectional study. A sample of 9,819 junior and senior high schools was selected for this study. The dependent variable was mental emotional disorder. The independent variables were smoking status, age, gender, education, absence of close friend, relationship with parents, being bullied, and alcohol consumption. The data was obtained from Global School-based Student Health Survey (GSHS) in 2015. The data was analyzed by a multiple logistic regression. Results: Mental emotional disorders increased with smoking status (OR= 1.60; 95% CI= 1.31 to 1.97; p= <0.001), being bullied (OR= 2.84; 95% CI= 2.45 to 3.30; p<0.001) and absence of close friendship (OR= 2.23; 95%CI= 1.59 to 3.14; p<0.001). Conclusion:Mental emotional disorders are associated with smoking, being bullied, and absence of close friendship.