Medicinal plants are now widely used for various purposes, such as preventing and treating diseases. One of the medicinal plants widely used as traditional medicines and already commercialized is Sonchus arvensis, known as show thistle and tempuyung in Indonesia. This mini-review will highlight information about traditional uses, phytochemical compounds, and biological activities of S. arvensis to increase our knowledge and understanding of this plant. We prepared this mini-review by finding sources of information in several scientific paper databases. As a traditional medicine, S. arvensis could be consumed to cure or prevent diseases. Secondary metabolites present in S. arvensis such as alkaloids, phenolics, flavonoids, and terpenoids are responsible for some biological activities of S. arvensis, such as antioxidant, antibacterial, anti-inflammatory, antihypertensive, antihyperuricemic, and antidiabetic activities.