No abstract

Background: MR Spectroscopy is a radiological examination using MRS supporting software in the MRI modality that can show the correlation of metabolic or biochemical anatomical and physiological information contained in the body, both in normal and abnormal conditions[1]. MRS is done after a routine brain without contrast or contrast. Proton MR spectroscopy of brain tissue shows the spectral of several metabolites[2]. Some of the main metabolites in brain tissue detected by MRS are NAA, Cholin, Creatinien, and Lipid, Lactate and Myo Inositol. MRS results are in the form of a graph showing the ratio of NAA levels per cholin to the patient's body metabolites and a graph on normal metabolites forming Hunter's angle[3].Methods: This method is a qualitative research with a descriptive approach using comprehensive literatures studies.Results: MRI and MR Spectroscopy examinations in cases of brain disorders will strengthen the diagnosis by looking at changes in the pattern of metabolites in the brain. Some characteristic spectrum patterns can be used as markers of certain diseases, so they can replace biopsy. MR Spectroscopy examination showed that online game addicts had lower levels of NAA concentrations than normal people in the right frontal cortex and lower levels of choline (Cho) in the medial temporal cortex.[4].Conclusion: MR Spectroscopy does not play a role in replacing MRI imaging, but as an addition to non-invasive metabolic information that has a high degree of accuracy for diagnosing abnormalities in brain regions by evaluating spectrum patterns or metabolite ratios. Latar Belakang: MR Spektroskopi merupakan pemeriksaan radiologi dengan menggunakan perangkat lunak pendukung MRS dalam modalitas MRI yang dapat menunjukkan korelasi informasi anatomis dan fisiologis metabolik atau biokimia yang terdapat dalam tubuh, baik dalam kondisi normal maupun abnormal[1]. MRS dilakukan setelah otak rutin tanpa kontras atau kontras. Proton MR Spektroskopi jaringan otak menunjukkan spektral beberapa metabolit [2]. Beberapa metabolit utama dalam jaringan otak yang terdeteksi oleh MRS adalah NAA, Kolin, Kreatinin, dan Lipid, Laktat dan Myo Inositol. Hasil MRS berupa grafik yang menunjukkan rasio kadar NAA per cholin terhadap metabolit tubuh pasien dan grafik metabolit normal membentuk sudut Hunter [3].Metode: Metode ini merupakan penelitian kualitatif dengan pendekatan deskriptif dengan menggunakan studi literatur yang komprehensif.Hasil: Pemeriksaan MRI dan MR Spektroskopi pada kasus gangguan otak akan memperkuat diagnosis dengan melihat perubahan pola metabolit di otak. Beberapa pola spektrum karakteristik dapat digunakan sebagai penanda penyakit tertentu, sehingga dapat menggantikan biopsi. Pemeriksaan Spektroskopi MR menunjukkan bahwa pecandu game online memiliki tingkat konsentrasi NAA yang lebih rendah daripada orang normal di korteks frontal kanan dan kadar Kolin (Cho) di korteks temporal medial lebih rendah.[4].Kesimpulan: MR Spektroskopi tidak berperan dalam menggantikan pencitraan MRI, tetapi sebagai tambahan informasi metabolik non-invasif yang memiliki tingkat akurasi yang tinggi untuk mendiagnosis kelainan pada daerah otak dengan mengevaluasi pola spektrum atau rasio metabolit.

Gadget addiction is one of the negative effects of excessive gadget use. Currently, there are many studies investigating internet addiction using a neuroimaging approach using diagnostic modalities. One of the modalities that can be used is Magnetic Resonance Imaging (MRI). One of the developments in MRI is the Magnetic Resonance Spectroscopy Imaging or MRS examination. MRS is a radiological examination that uses MRS supporting software in the MRI modality which can show correlations of anatomical and physiological metabolic or biochemical information present in the body, both in normal and abnormal conditions. The purpose of this study was to analyze the results of metabolite values in adolescents with suspected gadget addiction to prevent and support therapeutic research using MRS. The method in this study is descriptive qualitative research used to determine the results of metabolite values in adolescents with suspected gadget addiction to prevent and support therapeutic research using MRS with the single voxel. The sample used is teenagers with suspected gadget addiction. The result of the MRS examination can show the value of metabolites in the adolescent's body. The results of the MRS are in the form of graphs of metabolite values. Normal metabolite values will produce Hunter's Angle. The graph of teenagers with suspected gadget addiction does not form a Hunter's Angle. The values of NAA (5,49), Cho (3,63), Cr (3,65) and Glx (1.06) in adolescents with suspected gadget addiction decreased from the normal values of NAA (10-15), Cho (8), Cr (7) and Glx value (5-10).