Funding Acknowledgements Type of funding sources: None. Background/Introduction Patients with heart failure (HF) usually have limited functional capacity which ultimately reduces the quality of life and increases mortality rates that burden the health care system, HF currently has the highest readmission rate among all medical conditions. Telecardiology is a modern method based on long-distance telecommunications that are practical to implement and has the potential to improve the outcome of HF patients. Purpose The purpose of this study was to determine the impact of telecardiology on mortality and quality of life of patients with HF Methods A systematic literature search was conducted on PubMed and Cochrane Library with the journal publication period was 2010-2021. The primary outcomes of this study were mortality and quality of life (QoL). Secondary outcomes were major adverse cardiac events (MACE), rehospitalization, and changes in left ventricular ejection fraction (LVEF). Telecardiology in this study covers telephone-based, software-based, and monitoring with devices. Risk Ratio (RR) with 95% CI was calculated using a random-effect model, and the Mantel-Haenszel method was used to combine RR. Results A total of 29 RCTs with 13,837 adult NYHA I-IV HF patients were included. The follow-up range was 1-26 months. Telecardiology resulted in statistically significant risk reduction of all-cause mortality (RR: 0.90 ; 95% CI:0.83,0.99; p=0.02), and significant improvement in quality of life based on the Minnesota Living with Heart Failure Questionnaire (MLHFQ) (p<0.00001 ). We were also found the incidence of rehospitalization (RR: 0.94; 95% CI:0.90,0.98; p=0.004) and MACE (RR: 0.58; 95% CI:0.55,0.62; p<0.00001) were significantly lower in the telecardiology population. when compared with the control population, but not significantly associated with changes in LVEF (p = 0.79). Conclusion(s) Telecardiology is proven to improve patient outcomes in terms of mortality and quality of life. A significant reduction in rehospitalization has the potential to reduce the national health burden.