Non Specific Orbital Inflammatory Disease (NSOID) is a benign, noninfective inflammatory condition of the orbit which does not have any identifiable local or systemic causes. Orbital pseudotumor was first described in 1903 by Gleason. The clinical diagnosis is one of exclusion with evaluation directed to exclude neoplasms, infections and systemic disorders. IOI is diagnosed by clinical history and evaluation to rule out other causes of orbital disease. Orbital pseudotumor is the third most common orbital disease following Graves ophthalmopathy and lymphoproliferative disease.
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