Non-venereal dermatoses include disorders involving genitalia which are not transmitted sexually. They are more likely to be confused with venereal diseases, which leads to diagnostic dilemma to physicians. Patients usually think of that they are suffering from some venereal diseases and can be a major concern to patient. MATERIALS & METHODS: It is a descriptive study of new cases with genital lesions among adults (which includes male patients above age of 18 years and excludes patients below 18 years of age, patients presenting with classical STDs, attending SKIN & STD outpatient clinic of Chettinad hospital and research centre for a period of one year from July 2018 to August 2019. RESULTS: A total of 216 cases with non-venereal genital dermatoses were encountered in our study. Majority of the patients were found in the age group of 26 -35 years [27.8 %]. Scabies was found to be the commonest NVGD, occurring in 56 (22%) patients. Pearly Penile Papule was seen more commonly [15 (7%)], among benign conditions and normal variants. CONCLUSION: All lesions occurring over genitalia are not necessarily sexually transmitted. Many other non-venereal conditions can occur over the genitalia. All clinicians should view and examine these conditions with an open mind and treat with appropriate drugs. Scabies was commonest non venereal genital dermatoses in our study.

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Aim: To compare the efficacy and safety of topical 3% tranexamic acid gel vs 35% glycolic acid peel in the treatment of melasma over face. Materials and Methods: This is an open labelled, Randomised Controlled Trial(RCT) conducted on 60 patients. Patients were randomly divided equally into 2 groups – Group A and Group B. Patients of Group A  used topical 3% tranexamic acid gel twice a day and Group B patients were treated with 35% glycolic acid peel with a contact period of 5 minutes once in every 2 weeks. Patients were assessed every month for a period of 3 months and recurrence was assessed for the next consecutive 3 months following the treatment. Patients were asked to use a broad spectrum sunscreen before sun exposure during the entire study. Assessment of reduction in pigmentation was made by MASI score, subjective and objective valuation (blind observer) and photographic comparison. Safety profile was assessed by the side effects. Results: The mean value of Melasma Area and Severity Index(MASI) score for glycolic acid group at baseline was 14.41 which reduced to 7.05 at end of 3rd month. In tranexamic acid group, the mean value of MASI score at baseline was 14.58 which reduced to 5.96 at the end of 3rd month. The mean percentage of improvement in MASI score in glycolic acid group 52% whereas in tranexamic acid group it is 61%.  The side effects were minimal in this study. Side effects were more in glycolic acid group than tranexamic acid group.  A total of 8 patients had recurrence during follow up. In glycolic acid group, 5 patients had recurrence whereas in tranexamic acid group, only 3 patients had recurrence. The percentage of recurrence in glycolic acid group is 16.7 % whereas in glycolic acid group it is 10.7%. Conclusion: Tranexamic acid is a novel emerging therapy for melasma. In this study it has been found that topical 3% tranexamic acid is equally efficacious as 35% glycolic acid peel with minimal side effects in the treatment of melasma.

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