Wellens' Syndrome (WS) is a clinical presentation of ischemic chest pain with deep and symmetrical T wave or biphasic T wave inversion in V1 or V2 until V4 or V5 in electrocardiography finding and critical lesion in proximal Left Anterior Descenden (LAD) coronary artery. This case report discuss male 51 year old with typical chest pain and the ECG showed deep T-wave inversion in V1-V5. Transient ST elevation in V1-V5 appeared in 4th day of hospitalization without increasing cardiac markers. Coronary angiography examination demonstrated critical stenosis in proximal LAD (90%). Here we discuss about Wellens' syndrome clinical manifestation, ECG and coronary angiography presentation, and also anterior wall Myocardial infarction as a consequences of WS. Early detection and prompt management can prevent anterior wall MI and mortality.