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Background Keloids are of utmost clinical concern with regard to the wound healing process caused by chronic inflammation. Today, many treatments have been executed but none have shown permanent results. Objective This study aims to find another possible keloid treatment using panduratin A, a phytochemical found in Boesenbergia rotunda (fingerroot) extract. Materials and Methods The effects of panduratin A on fibroblast proliferation and migration were assessed by scratch wound healing assays. Results Panduratin A inhibited wound closure in a dose-dependent manner. The wound region at 24 hours using 2.5, 5, 10, 20 µM panduratin A was significantly larger than the wound region of 0 µM panduratin A (3.6 x 106, 5.6 x 106, 6.5 x 106, 7.5 x 106 vs 1.8 x 106 µm2, p = 0.0011, p < 0.0001, p < 0.0001, p < 0.0001, respectively). Discussion Panduratin A inhibited fibroblast cell migration and proliferation. Many studies found that panduratin A inhibits the release of cytokines related to the pathogenesis of keloids; these include transforming growth factor (TGF)-β1, platelet-derived growth factor (PDGF), matrix metalloproteinase-2 (MMP-2), and tissue inhibitor of metalloproteinase-1 (TIMP-1). Conclusion These results propose that panduratin A could be a possible modality for inhibiting keloid formation.

Background: Acupuncture shows benefits for patients with melasma, although no optimal number of sessions have been determined.Methods: The prospective observational study was conducted in melasma patients who were treated with acupuncture procedures two times a week and were evaluated after the 5th and the 10th sessions of acupuncture, with a 1-week follow-up after the last session. Participants Groups A and B received five and 10 acupuncture sessions, respectively. Melasma was assessed by using the melanin index (MI), melasma area and severity index (MASI), patient-reported improvement scores, and acupuncture-related adverse events.Results: Out of 113 participants, 67 received five sessions of acupuncture treatment while 39 received 10 sessions. At 1 week after five sessions of acupuncture in Group A, the mean MI decreased by 28.7 (95% CI −38.5 to −18.8, p &lt; 0.001), whereas the median MASI decreased by 3.4 (95% CI −6.9 to −1.2, p &lt; 0.001) points. At 1 week after ten sessions of acupuncture in Group B, the mean MI decreased by 31.3 (95% CI −45 to −17.6, p &lt; 0.001), whereas the median MASI decreased by 5.4 (95%CI −9.9 to −3, p &lt; 0.001) points. The first five sessions of acupuncture had a higher incremental effect than the last five sessions, although there was no statistically significant difference. Twenty-nine participants reported minor side effects. Group B had a risk ratio (RR) of having adverse events 1.8 times (95% CI 1.0–3.4, p = 0.05) compared with Group A.Conclusion: Short acupuncture regimens of 5–10 sessions in melasma seem to be effective and practical with minor side effects.