No abstract

This paper explores the individual and group motivations that have encouraged the onward migration of Italian-Pakistanis and Italian-Bangladeshis to the North of England after obtaining Italian citizenship because the reasons for moving again to the current destination are under-researched. It appears that there has been a design-driven form of intentionality in their complex migrations attributable to the influence of European and Italian policies. Gender and ethnic differences among these groups are identified, as well as the level of their integration in the new host country. A qualitative research approach is adopted utilizing six focus group discussions with 48 participants, and the data collected were subjected to thematic analysis. The findings revealed that aspects of education and qualifications, religion, social identity, and culture along with welfare, security, and employment were the motivations for the participants’ onward migration.

CDKN2A pathogenic variants are well known to be associated with cutaneous melanoma and noncutaneous tumors (NCTs). Herein, we investigated the temporal correlation between the first cutaneous melanoma and NCT both in CDKN2A mutation carriers (MUT) and in wildtype melanoma patients, a poorly explored issue to date. Two hundred forty-five cutaneous melanoma patients were genotyped for the CDKN2A gene and divided into 51 MUT and 189 wild-type; the remaining five variant carriers were excluded from the analyses. MUT developed a significantly higher number of cutaneous melanoma than wild-type, while 13.7% in both genotyped groups received a diagnosis of at least one malignant NCT, without statistically significant differences. The onset of the first cutaneous melanoma preceded that of the first malignant or benign NCT in both MUT and wild-type patients by an average of 4.5 and 3.02 years, respectively. Considering only malignant tumors, the diagnosis of melanoma preceded that of the first NCT on an average of 8 and 4.34 years, in MUT and wild-type patients respectively. We emphasize the relevance to adopt a global vision for the primary and secondary surveillance of patients affected by cutaneous melanoma, not only limited to high-risk for multiple primary skin cancers but also to NCT that may develop several years after the diagnosis of the first cutaneous melanoma. Melanoma Res 33: 425-430