Early pregnancy failure a b s t r a c tBackground: Nearly 20% of all confirmed pregnancies end in spontaneous abortion. Misoprostol's use in early pregnancy failure is varied and dose and route are not well established. The aim of this study was to compare the efficacy and the side effects of different regimes of misoprostol in causing expulsion of products of conception in early pregnancy failure.Method: Women patients with an ultrasound diagnosis of early pregnancy failure, less than 12 weeks gestation were divided into two, Group-A: tab. Misoprostol 800 mcg 6 hourly vaginally, upto 3 doses. Group-B tablet misoprostol 600 mcg 6 hourly, sublingually for 3 doses. All observations were noted and statistical analyzed.Results: Mean gestational age was 7.93 weeks. Mean induction abortion interval 18.183 h.Women patients with less than six weeks gestational age had least mean inductionabortion interval time, 15.75 ± 2.82 h in vaginal group but was highest in sublingual group 22 ± 2 h and 18.43 h in overall (P ¼ 0.02). Though after 8 weeks, both routes were equally effective. Mean dose required in group-A was 20044 mcg and in group-B was 1564 mcg (P < 0.001). Efficacy of protocol was 88.89% in group-A and 92.85% in group-B. Conclusion:Both regimes had comparable efficacy, acceptability (90%) and side effects. In women patients less than six weeks period of gestation, the vaginal (800 mcg) route was distinctly superior, in women patients with 6e8 weeks the sublingual (600 mcg) route was more advantageous. The correct dose must be used for the route chosen. The route of administration should be decided in accordance with the preference of the patient and the clinical situation.© 2014, Armed Forces Medical Services (AFMS). All rights reserved.* Corresponding author. Tel.: þ91 (0)9828025302 (mobile). E-mail address: hoojasjaipur@gmail.com (N. Hooja).Available online at www.sciencedirect.com ScienceDirect journal homepage: www .e lsev ie r. co m/ lo cate/ mj afi m e d i c a l j o u r n a l a r m e d f o r c e s i n d i a 7 0 ( 2 0 1 4 ) 3 6 0 e3 6 3 http://dx

INTRODUCTIONOne third of outpatient"s visits to the gynaecologists are for abnormal uterine bleeding (AUB), and it accounts for more than 70% of all gynaecologic consults in the perimenopausal and postmenopausal years. The International Federation of Gynaecology and Obstetrics (FIGO) has proposed a classification system for 9 major causes of AUB (PALMCOEIN).2 and the likely cause of abnormal uterine bleeding is usually related to age. Abnormal bleeding caused by hormone imbalance is more common in teenagers or in women who are approaching menopause. Obesity, PCOS, anorexia or crash diets, stress and extreme exercise account can all disrupt normal ovulatory function and may be considered as preventable risk factors for AUB.3 There has been a move to describe AUB in terms of its impact on a woman"s physical, emotional, social and material quality of life (QOL).Though few studies have been done to assess the burden of AUB on society however, the knowledge of women regarding various aspects of AUB and its association with their socio demographic status had never been assessed. Hence, the study was undertaken to assess the knowledge and attitude of women with AUB in relation to their education level and socio economic status. METHODSThis was a cross sectional descriptive study carried out among women with AUB. Two hundred women with ABSTRACT Background: Abnormal uterine bleeding (AUB) is a common but overlooked condition. The lack of information and poor attitude towards health is often the reason. The knowledge of women regarding AUB and the preventable factors and its association with their education and socioeconomic status has never been assessed. Hence, the study was undertaken to assess the knowledge and attitude of women with AUB regarding the condition, its etiology, risk factors and treatment modalities in relation to their education and socio economic status. Methods:The cross sectional descriptive study was carried out among women with AUB. Structured interviewer administered questionnaire was used to collect the required information. Knowledge of AUB and its risk factors from women with AUB were given scores 1-8 and 1-6 respectively. Information on education and socioeconomic status was also noted. Statistical analysis of data was done. Results: Knowledge score for AUB ≤4 and its risk factors ≤3 was found in 63% and 72% of respondents respectively. Poor reading ability and low socio economic status was significantly associated with poor knowledge scores. Conclusions:Intensive enlightenment of population using the mass media by trained personnel and strengthening of primary health care services is recommended.

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