Pain management is very crucial in nursing care. However due to lack of overall understanding, pain management by health professional is scarce. Therefore, knowledge and attitude of nurses towards effective management of pain in care post-operative care is pertinent. The effectiveness of postoperative nursing care is a basic part of a healthcare worker. The type of post-operative management emphasized in this article consists of the pain assessment and pain management by pharmacological and non-pharmacological tools. Post-operative follow-up care is required to alleviate pain and restore knee features and functions. The primary duty of nurses in postoperative care is to acknowledge preparation and implement suitable treatment. This article aims to provide information on increasing nurses’ knowledge in managing pain for post-operative care of Total Knee Replacement. Searches were performed by using electronic database for full text article in English language, original article published between 2000 and 2021. The database includes Springer, PubMed, British Medical Journal, Malaysian Orthopaedic Journal, SAGE Pub and ProQuest.