<p class="0abstract">Digital devices such as mobile phone, personal computer and laptop are playing a major role in students’ life, but if overused they can bring certain impacts on the musculoskeletal system. <strong>Objective: </strong>To determine the relationship between usage of digital devices and musculoskeletal symptoms among the university students. <strong>Method</strong>s: A self-administered questionnaire consist of digital devices use items and the Cornell Musculoskeletal Discomfort Question (CMDQ) were administered among<span style="text-decoration: line-through;"> 363</span> 311 university students. Correlation analysis was done by using the SPSS software. <strong>Results:</strong> The mean age of study respondents was 21.6 years old (SD=1.0). A majority of respondents use mobile phone (94.9%) on a prolonged sitting position ranging from 5.0 to 7.5 hours per day. About 32% to 60% of respondents experienced musculoskeletal discomfort in at least one body part<span style="text-decoration: line-through;"> at least one on their body parts</span>, with higher prevalence on the neck, shoulder, lower back, and upper back. Females are more prone to experience musculoskeletal symptoms. Time spent on digital devices, eye-to-screen distance, body posture, and age of first use were significantly correlated with musculoskeletal symptoms. <strong>Conclusions:</strong> University students are at a higher risk to experience musculoskeletal symptoms related to the usage of a handheld digital device. If these musculoskeletal symptoms are not prevented, it may further cause dysfunction and disability. To mitigate these problems, some form of targeted health promotion initiative need to be implemented in the university.</p>