Handling children with chronic diseases may negatively impact caregivers' quality of life. This research objective is to identify the caregiver burden in children with chronic disease care. A cross-sectional study used the PedsQl Family Impact Module questionnaire to identify the caregiver burden among 230 caregivers of children with chronic diseases at UMCC. The participant perceived burden (n=154, 67%) with mean M=1.67 (SD 0.47). However, age and gender are not significantly associated with caregiver burden. In conclusion, caregivers perceive the burden of caring for children with chronic diseases. Therefore, continuous support from healthcare providers may help reduce the caregiver burden. Keywords: Caregiver, burden, children, chronic disease eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v7i20.3300