Objective: This review aimed to determine the issue associated with patient’s readmission to intensive care units (ICU) within 24 to 72 hours. Methods: A mixed-method systematic literature review was carried out with 16 articles which published within the year of 2010 to 2020. Result: Three themes were found related to ICU readmission; predictors, factors, and recommendation. The predictors were Acute Physiological Chronic Health Evaluation (APACHE), Stability and Workload Index for Transfer (SWIFT), Therapeutic Intervention Scoring System (TISS) and others. The factors contributing to ICU readmission which are higher score level of tools used, severity of illness, discharge time, hemodynamic monitoring and patient’s conditions before discharge. The recommendations to reduce the ICU readmission from this review were ICU follow-up program, new staff nurses should be supported by senior staff, change of ICU discharge process, and introduce an intermediate unit. Conclusion: This review findings recommended that there is a need for a follow-up program by ICU nurse-led, the use of semi-intensive units and implementing transition programs of critical care for patients readmitted to ICU within 72 hours. Thus, more effort should be made to reduce the ICU readmission within 24 to 72 hours to improve the quality of patient’s life.