COVID-19 causes worldwide panic and become a global health problem so that it is declared as pandemic since December 2019. Indonesia is a country with 4th population density in the world. The level of spread of COVID-19 patients in Indonesia may be more than countries with smaller populations. South East Sulawesi has confirmed 484 of COVID-19 cases. One of the highest areas with the number of patients is Bombana Regency. The purpose of community service carried out by lecturers and students from Halu Oleo University was to strengthen the role of the people of Bombana Regency in mitigating and adapting to the COVID-19 pandemic. Activities in community service included education and socialization of GEMAS, antiseptics, and disinfectants which were carried out offline (door to door) and online. As well as the distribution of masks and spray hand sanitizer for free. Through this activity, it can be expected to increase public knowledge and awareness in using masks, antiseptics, and disinfectants properly to face COVID-19 pandemic.

The Ghontohge plant (Kleinhovia hospita L.) has been used as a traditional medicine to treat scurvy, lice, eye pain, jaundice and hepatitis, cholesterol, diabetes, hypertension and treat pneumonia. Therefore, it is possible that plants can be used as antioxidants and redox signalling sourced from natural materials. The purpose of this study was to investigate the antioxidant potential and evaluate the total phenolic and flavonoid content of Ghontoghe leaves and investigate the most potent fraction as an antioxidant from the extract and fractions of Ghontoghe leaves. Ghontoghe leaf powder was extracted using the maceration method. Antioxidant activity was evaluated using 2,2-diphenyl-1-picryhidrazyl (DPPH) and 2,2-Azinobis 3-ethyl benzothiazoline 6-sulfonic acid radicals (ABTS). The total phenolic content was determined using the Folin-Ciocalteau method. Meanwhile, the total flavonoid content was determined using the aluminium chloride complex colourimetric method. The ethyl acetate fraction showed the strongest antioxidant activity on both DPPH radicals and ABTS radicals with IC50 values of 6.253±0.008 g/mL and 6.486±0.023 g/mL, respectively. The ethyl acetate fraction also showed high phenolic and flavonoid content with values of 26.92±0.10 mg GAE/g sample and 95±0.69 mg QE/g sample, respectively. The ethyl acetate fraction has the potential to be used as a source of natural antioxidants and has the potential to be used as a functional food.

Free radicals are electron-deficient species that are very reactive to cause various diseases, such as diabetes, cholesterol, cardiovascular disease, cancer, hypertension, and others. For this reason, antioxidant compounds are needed that can inhibit the performance of free radicals. Caco is a plant that contains many phenolic and flavonoid compounds that have potential as antioxidants. This study aimed to evaluate the total phenolic and flavonoid content as well as in vitro antioxidant assay. Cocoa fruit powder was macerated with methanol, and then fractionated with n-hexane, chloroform, and ethyl acetate as solvents. The antioxidant power was measured by DPPH and ABTS methods. The phenolic content was determined by the Folin-Ciocalteau method, and the flavonoid content was measured using the AlCl3 colourimetric method. The ethyl acetate fraction showed the strongest antioxidant activity using both the DPPH and ABTS methods with IC50 values of 5.61±0.032 mg/mL and 5.773±0.018 mg/mL, respectively. The total phenolic and flavonoid content of the ethyl acetate fraction showed high values, namely 22.767±0.1097 mg GAE/g sample and 90.337±0.552 mg QE/g sample, respectively. The cocoa peel can be developed as a natural antioxidant and can be used as a functional food.

Diabetes Melitus (DM) adalah penyakit yang disebabkan oleh ketidakseimbangan asupan insulin sehingga menyebabkan glukosa tidak dapat diubah menjadi glikogen. Tectona grandis Linn F. atau daun jati secara empiris digunakan oleh masyarakat untuk pengobatan dan diketahui memiliki aktivitas sebagai antidiabetes. Penelitian ini bertujuan untuk mengetahui profil kada glikogen dalam hati dan otot tikus putih jantan model DM tipe II setelah pemberian fraksi n-heksan, kloroform, dan etil asetat daun jati. Penelitian dilakukan dnegan menggunakan Post Test Only with control group design dan pengujian kadar menggunakan metode spektrofotomteri. Hasil penelitian menunjukkan kadar glikogen hati hewan uji pada kelompok kontrol normal (Kn), kontrol positif (K+), kontrol negatif (K-), kelompok fraksi n-heksana (K1), fraksi kloroform (K2), dan fraksi etil asetat (K3) dengan dosis masing-masing 300 mg/kgBB berturut-turut yaitu 41,24; 46,14; 34,67; 43,00; 46,85; dan 52,70 µg/100mg sampel hati serta kadar glikogen otot masing-masing kelompok berturut-turut yaitu 24,82; 26,62; 19,51; 13,88; 15,43; dan 20,05 µg/100mg sampel otot. Berdasarkan hasil penelitian dapat disimpulkan bahwa fraksi terbaik yang dapat meningkatkan kadar glikogen hati dan otot hewan uji yaitu fraksi etil asetat dengan dosis 300 mg/kgBB.