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Background:Left ventricular hypertrophy (LVH) is a common pathological change in hypertension, which is a marker for cardiovascular events and mortality. Inflammation as well as ischemia play significant roles and are the leading pathways in left ventricular remodeling. Thus, neutrophil-to-lymphocyte ratio (NLR), an inflammatory marker, was suggested to be predictive of LVH in hypertensive patients.Objective:Our aim was to review all studies that assessed the value of NLR in predicting LVH in hypertension.Methods:We performed a systematic literature search on the topic from several electronic databases (PubMed, Europe PMC, ProQuest, EBSCOhost, and Google Scholar) from inception to January 2021. The standardized mean difference (SMD) with 95% confidence interval (CI) were estimated and pooled to investigate the effect sizes.Results:Meta-analysis of two studies showed that increase in NLR was associated with higher risk of developing LVH in patients with hypertension (SMD = 0.68, 95% confidence interval [CI] = 0.12–1.25, Z = 2.36, P = 0.02) compared with control group. Additionally, further subgroup analyses of LVH categorization stratified by Ganau's classification showed significant higher NLR value in eccentric LVH subgroup (SMD = 1.22, 95% CI = 0.08–2.36, Z = 2.11, P = 0.04) although no significant difference was observed in other three subgroups.Conclusion:In this current meta-analysis, we concluded that NLR is a reliable and inexpensive biomarker to help determine risk of developing LVH in patients with hypertension.

Background:A large number of studies have reported the relationships between serum lactate dehydrogenase (LDH) and prognosis of pre-eclampsia. However, the result is still controversial and no consensus has been reached.Objective:The aim of the study was to find out the role of serum LDH in prediction of poor maternal and perinatal outcomes in patients with pre-eclampsia.Methods:We performed a systematic computerized search for eligible articles from PubMed, Europe PMC, ProQuest, EBSCOhost, and Google Scholar databases from inception to January 2021. The pooled odds ratio (OR) and 95% confidence intervals (CIs) of all events of interest and event-free subjects were obtained to assess the predictive value of serum LDH in predicting composite poor outcomes.Results:A total of 11 studies that assessed patients with pre-eclampsia were included. Overall, elevated serum LDH level in pre-eclamptic patients was associated with poor maternal and perinatal outcomes [pooled OR: 7.92 (95% CI = 5.75–10.93); pooled OR: 8.08 (95% CI = 4.40–14.83) respectively]. Subgroup analyses showed that elevated LDH also increased risk of placental abruption, disseminated intravascular coagulation, acute renal failure, eclampsia, and HELLP syndrome. The resulting P-value showed no heterogeneity among articles (P > 0.01). No evidence of asymmetry was shown in the funnel plot, thus no publication bias existed in the included studies.Conclusions:This meta-analysis demonstrates that elevated serum LDH level is apparently associated with poor outcomes in patients with pre-eclampsia and serum LDH could be a prognostic biomarker for pre-eclamptic patients.

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