Background: Biological systems can be modeled as complex network systems with many interactions between the components. These interactions give rise to the function and behavior of that system. For example, the protein-protein interaction network is the physical basis of multiple cellular functions. One goal of emerging systems biology is to analyze very large complex biological networks such as protein-protein interaction networks, metabolic networks, and regulatory networks to identify functional modules and assign functions to certain components of the system. Network modules do not occur by chance, so identification of modules is likely to capture the biologically meaningful interactions in large-scale PPI data. Unfortunately, existing computer-based clustering methods developed to find those modules are either not so accurate or too slow.

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Many systems in sciences, engineering and nature can be modeled as networks. Examples include the internet, WWW and social networks. Finding hidden structures is important for making sense of complex networked data. In this paper we present a new network clustering method that can find clusters in an agglomerative fashion using structural similarity of vertices in the given network. Experiments conducted on real datasets demonstrate promising performance of the new method.2009 Advances in Social Network Analysis and Mining 978-0-7695-3689-7/09 $25.00

Graph partitioning, or network clustering, is an essential research problem in many areas. Current approaches, however, have difficulty splitting two clusters that are densely connected by one or more "hub" vertices. Further, traditional methods are less able to deal with very confused structures. In this paper we propose a novel similarity-based definition of the quality of a partitioning of a graph. Through theoretical analysis and experimental results we demonstrate that the proposed definition largely overcomes the "hub" problem and outperforms existing approaches on complicated graphs. In addition, we show that this definition can be used with fast agglomerative algorithms to find communities in very large networks. 11.