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Giriş:Hastane kökenli ya da sağlık bakımı ile ilişkili enfeksiyonların (HE) görülme sıklığı ülkeden ülkeye, hatta aynı hastanenin farklı birimlerine göre değişebilmektedir. Prevalans çalışmaları ile hastanelerdeki enfeksiyon sorunu daha geniş bir perspektifte tüm hastaneyi kapsayacak şekilde ortaya konulabilir ve kontrol önlemleri bu kapsamda değerlendirilebilir. Bu çalışmada bir üçüncü basamqk eğitim hastanesi olan hastanemizde 23 Aralık 2013 tarihinde yatan hastalardaki HE prevalansı irdelenmiştir. Gereç ve Yöntem: Bin sekiz yüz elli yatak kapasiteli hastanemizde (1,516'sı erişkin, 334'ü pediatrik ve toplam 328'i yoğun bakım yatağı), 23 Aralık 2013'de yatmakta olan hastalardan, ilgili bölüm enfeksiyon hastalıkları ve klinik mikrobiyoloji konsültan hekimleri tarafından HE tanısı konulan hastalar altta yatan hastalıklar, risk faktörleri, uygulanan tıbbi girişimler, enfeksiyon odakları ve etken mikroorganizmalar açısından değerlendirilmiştir. Bulgular: Prevalans çalışmasının yapıldığı 23 Aralık 2013'de yatan hasta sayısı 1,470, HE prevalansı %7,21 olarak saptanmıştır. Hastalarda en sık görülen HE tipi pnömoni olup, diğer HE odakları sırasıyla idrar yolu enfeksiyonu, bakteriyemi, cerrahi alan enfeksiyonları ve intraabdominal enfeksiyonlar şeklinde sıralanmıştır. Sonuç: Hastanemiz gibi büyük hastanelerde tüm kliniklerde hastaya dayalı, aktif sürveyans yapılamadığı durumlarda, uygun aralıklarla tekrarlanan nokta prevalans çalışmalarının HE izleminde ve etkili enfeksiyon kontrol önlemleri alınmasında yararlı olacağını düşünüyoruz. Anahtar Kelimeler: Hastane enfeksiyonu, nokta prevelans, sürveyans, sağlık bakımı ilişkili enfeksiyonlar, nozokomiyal enfeksiyon Introduction: The prevalence of hospital-acquired or healthcare-associated infections (HAI) varies from country to country even between different units of the same hospital. By the help of prevalence studies, HAI rates can be demonstrated in a wider perspective and, based on these data; infection control measures may be reevaluated. In this study, we investigated the HAI prevalence in hospitalized patients on 23 December 2013 at our tertiary-care educational hospital. Materials and Methods: On 23 December 2013, patients diagnosed with HAI (by using Centers for Disease Control and Prevention criteria) by infectious diseases and clinical microbiology specialists in our 1850-bedded (including 1.516 adult, 334 pediatric and a total of 328 intensive care unit beds) tertiary-care hospital, were evaluated in terms of underlying disease, risk factors, implementation initiatives, focus of infection and causative microorganisms. Results: The number of patients hospitalized on 23 December 2014 was 1.470, the prevalence of HAI was found to be 7.21%. The most common type of HAI was pneumonia followed by urinary tract infection, bacteremia, surgical site infections and intra-abdominal infections. Conclusion: We conclude that repeated HAI prevalence studies at appropriate intervals are very useful for taking effective infection control measures and follow-up of HAI in large hospi...

BackgroundCRE are globally important pathogens associated with significant morbidity and mortality. The problem of carrying CRE may continue to create a problem in discharged cases in the community. Saccharomyces boulardii sachet therapy (SBST) is reported to cause decolonization in several MDR bacteria carriers. Herein, it is aimed to present the decolonizing rates of rectal CRE colonized cases after SBST treatment.MethodsThe study period was August 2018–March 2019. Inclusion criteria were: (i) age >18, (ii) receiving Saccharomyces boulardii 250 mg sachets q12h for 7 days, (iii) being proven CRE carrier on rectal swab culture (RSC) up to 5 days period before SBST. The first repeated RSC was performed 3–5 days after the end of SBST. Data were retrieved from the hospital electronic database. Cases with three consecutive weekly performed negative RSC were considered to be decolonized. RSC were processed according to CDC protocol; briefly, the swab was inoculated into 10 mL of trypticase soy broth (bioMérieux Inc., Marcy-l’Étoile, France) with the addition of one 10-μg ertapenem disk (Oxoid, Altrincham, UK) and incubated at 35°C for 18–20 h. The next day, after vortexing, 100 μL of the inoculum was subcultured (8) onto chromID CARBA agar plates (bioMérieux) and incubated at 35°C for 18–20 h. Suspected CRE colonies on chromID CARBA (blue/green to blue/gray in color) were identified by the VITEK MS system (bioMérieux). Susceptibility testing of the isolates was performed with the VITEK 2 system (bioMérieux). Isolates were tested for their resistance phenotypes to imipenem, ertapenem, and meropenem by E-test (bioMérieux). The results were interpreted according to the EUCAST criteria.ResultsFifteen cases [2 women, mean age 60.6 ± 18.3 (min. 18–max. 83)] fulfilled the inclusion criteria. All had a history of carbapenem usage. Five cases (33%) had three consequent negative RSC after SBST and were considered to be decolonized. Twelve cases were receiving concomitant antibiotic during SBST (10 carbapenem based regimens). Three cases who received no concomitant antibiotic were decolonized.ConclusionSBST may be a promising tool for decolonizing CRE carriers. These data need to be validated in larger cohorts preferably via randomized-controlled trials.Disclosures All authors: No reported disclosures.

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