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Treatment of patients with bisphosphonate usage is a significant concern for oral surgeons because it interferes with jaw bone turnover and regeneration. In case of adverse effects manifesting related to bisphosphonate use, oral surgeons are usually treating and keep the patient's symptoms under control. In this study, we aimed to investigate a new treatment protocol for medication-related osteonecrosis of the jaw (MRONJ). This treatment protocol consisted of administering human parathyroid hormone (hPTH) loaded chitosan microspheres which were prepared by ionotropic gelation method or/and the prepared microspheres were suspended in a poloxamer gel. After in-vitro optimization studies, the efficacy of the chosen formulations was evaluated in-vivo studies. Zoledronic acid was administered daily to forty-eight adult female Sprague-Dawley rats, divided into four experimental groups, at a daily concentration of 0.11 mg/kg over three weeks to induce the MRONJ model. At the end of this period, maxillary left molar teeth were extracted. In the first group, the subjects received no treatment. In the negative control group, poloxamer hydrogel containing empty microspheres were immediately applied to the soft tissues surrounding the extraction socket. The treatment group-1 was treated with local injections of poloxamer hydrogel containing hPTH. The treatment group-2 was treated with a single local injection of poloxamer hydrogel containing hPTH-loaded chitosan microspheres. Both treatment groups received a total of 7 µg of hPTH at the end of the treatment protocol. Our study demonstrates successful attenuation of MRONJ through a local drug delivery system combined with hPTH, as opposed to previously attempted treatment strategies.

The objective of the present in vitro study was to evaluate micro-tensile bond strength (µSBS) of MTA cements to composite resin using a universal adhesive after internal bleaching procedure, and to examine surface characteristics of MTA cements exposed to bleaching agents. MTA specimens were divided into three subgroups according to the bleaching agent used which were, 37% carbamide peroxide (CP), 35% hydrogen peroxide (HP), and no exposure as a control group (n = 12). After exposure to bleaching agent, composite resins were applied to MTA surfaces using a universal adhesive in self-etch mode. The specimens were exposed to a shear force until failure to evaluate bond strength. MTA surfaces were investigated using scanning electron microscopy (SEM) to observe the effects of the bleaching agents. Differences between groups were analyzed using two-way ANOVA test and intergroup comparisons were assessed with Tukey test (p < 0.05). Although there was a slight difference in bond strength between bleaching agents (CP and HP), no significant difference was found, irrespective of MTA cement. After the HP application, the bond strength values decreased approximately by half compared with the controls. SEM results demonstrated distinct morphological differences between the intact MTA surface (control) and treated MTA surface. Distinct micro-cracks, surface irregularities, and capillary voids formed due to the superficial dissolution caused by peroxides. Exposure to the intra-coronal bleaching agents had a negative influence on the surface morphology of MTA cements and their bond strength to composite resin. KeywordsAdhesion • Bond strength • Intra-orifice barrier • Intra-coronal bleaching agents • Mineral trioxide aggregate * S. Sismanoglu

No abstract

Cementifying fibroma is an uncommon neoplasm composed by varying amounts of cementum, bone and fibrous tissue. As a results of having similar histolological features based on inactive-looking odontogenic epithelium embedded in a fibrous stroma, it is often hard to differentiate from other fibro-osseous lesions such as fibrous dyplasia and calcifying odontogenic tumor. At this point, it is undoubtedly clear that proper radiological and clinical diagnosis play a great role together in identification. We present a rare case of this entity along with a number of clinical and radiographic features that set it apart from other pathologies mimicking fibro-osseous lesions.