Objective: To study the characteristics of balance performance in a sample of patients with increasing postural instability after acquired brain injury (ABI), and to establish the clinical utility of a new computerized posturographic system (NedSVE/IBV). Methods: We included 108 patients with ABI divided into five groups from minimal to severe postural impairment. All patients were assessed with the NedSVE/IBV system and with traditional balance measures.Posturographic analyses included the modified clinical test of sensory interaction on balance, the limits of stability, and the weight-shifting test.Sensitivity to detect changes and reproducibility were evaluated in sixty-three patients who were followed-up for 6 months and in 20 patients who were evaluated on two separate occasions during the same week, respectively.Results: Our patients showed reduced stability limits, abnormal postural responses, and an increased reliance on visual input with differences in intensity directly related to their degree of balance impairment. Posturographic study showed excellent convergent validity, reproducibility, and sensitivity to detect changes. Conclusion: Our data suggests that regardless of the intensity of postural instability, there is a common mechanism of sensory processing to maintain balance after ABI. The NedSVE-IBV system is a valid tool to quantify balance after ABI.