Nutrition is fundamental for brain development, but relatively little is known about water-soluble vitamin (WSV) levels and the effect of supplementation on psychiatry symptoms in children and adolescents (CAD) with psychiatric disorders. Our team systematically reviewed all studies concerning WSV abnormalities or supplementation in CAD with any psychiatric disorder. We searched for original studies published between 1990 and 15/05/2020 which were not based on retrospective chart review and which included WSV blood level measurements or investigated the effect of WSV supplementation on psychiatric symptoms in psychiatric patients aged 18 or under. Forty-two articles were included, 69% of which (N=29) examined Autism Spectrum Disorders (ASD), with most of these assessing folate or vitamin B12 supplementation (N=22, 75.9% of ASD studies). Meta-analyses showed significantly lower vitamin B12 levels in ASD and ADHD patients vs. healthy controls (HC), while folate levels were higher in ADHD patients vs. HC. Most of the studies (9/10, 90%) showed a decrease in symptoms as measured by clinical scales after supplementation. There was significant heterogeneity between the studies, however many found different types of vitamin abnormalities in CAD with psychiatric disorders.

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Due to COVID-19, many countries, like Spain, imposed lockdown on the entire population to prevent the virus from spreading. The purpose of this exploratory study is to investigate the severity of psychological symptoms, dyadic adjustment, and parental stress of parents during the first three weeks of the outbreak. It also aims to identify several risk factors that contribute to this distress. A total of 727 parents completed a form on an online platform with sociodemographic data, BSI- 18, EAD-13, and the Spanish version of the PPS. Linear regression analyses were used to explore the significant associations between the sample characteristics (sociodemographic variables and their lockdown circumstances) and parents’ psychological symptoms, dyadic adjustment, and parenting stress level during the COVID-19 epidemic. Most parents maintained good emotional, personal, conjugal, and family stability; however, female gender, not living with the partner, having a child with a mental disorder and were unable to balance the work and family lives were significantly associated with greater psychological distress. Being receiving psychiatric or psychological treatment has also been associated with poorer psychological and partner adjustment during the outbreak. It is essential to continue researching the impact of lockdowns on families so that, both the government and public health authorities, can offer resources to the most vulnerable families.

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