Objective: Clinical clerkship students, as adolescent health workers, have been first recipients of the COVID-19 vaccination programme. The success rate and trust of recipients in the program have been impacted by adverse events following immunization (AEFI). This study aims to determine the AEFI of the CoronaVac vaccine among clinical clerkship students at the Faculty of Medicine, State Islamic University, Jakarta. Material and Methods: This study used cross sectional methods with a total of 225 subjects completing a questionnaire. The CoronaVac vaccine was administered twice with 2 week interval. AEFI was evaluated after 30 minutes, 24 hours, and on the third day. Results and discussion: 73.3% of the participants were female, 20-25 years old. AEFIs were found in 57.8 % of all participants in the first and second doses vaccination. The most common local AEFI was pain at the site injection, accounting 27.1 % which occurred 30 minutes after second dose vaccination. The most common systemic AEFI was drowsiness, accounting for 18 % which occurred 24 hours after first dose vaccination. Other systemic AEFIs were headache, fatigue, and chills. There was significant association between AEFIs and females but no significant association with history of allergy, comorbidities, and history of previous COVID-19 . AEFIs were mild, no special treatment or hospitalization were required. Conclusion: The AEFIs of the CoronaVac vaccine among students were mild and had significant association with females. The study is expected to increase the public’s confidence in the COVID-19 vaccination program and to create awareness of its safety. Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page :545-552

Background: Smoking is a form of risky behavior that often starts in adolescence and is continued into adulthood. There has also been an increase in the use of vaping among adolescents. Adolescents who smoke have a double the risk of having depression symptoms compared to those who don't smoke. Objectives: This study aimed to investigate smoking and vaping behaviors and the experience of depressive symptoms among high school students in Jakarta, Indonesia. Materials and Methods: This cross-sectional study used the Youth Risk Behavior Surveillance (YRBS) 2017 questionnaire. Participants included 238 students aged between 15 and 19, randomly chosen from three senior high schools in Jakarta. Results: We found that 21.5% of students frequently smoked in the last 30 days, and 8.1% vaped repeatedly. However, 70.5% of them tried vaping. Moreover, within the last 12 months, approximately 8.5% of the students attempted suicide at least once. Also, 32.9% of them felt sad and hopeless for two weeks. Interestingly, we found that 54.1% of the students who felt sad were frequent smokers, and 43.5% were regular vapers. Conclusions: This study showed that risky behaviors like smoking and vaping were prevalent among senior high school students in Jakarta. Students who smoked or vaped exhibited depressive symptoms. Therefore, smoking and vaping could affect mental health in adolescence.

Background: as is known, epigenetic events are defined as modifications in phenotype or gene expression, which caused by interactions between genes and the environment without changing the order of their nitrogenous bases. This article will discuss the role of epigenetics in one of the degenerative diseases that are often found in the elderly, namely hypertension. In this review article, we will mainly discuss the events of histone modification and DNA methylation, for example, DNA methylation in the CpG islands and the acetylation of histone pathway are identified to limit the development of nephrons, thus opening up to lhypertension-related with exposure to high salt diets. Results: lack of maternal water and protein deficiency have been shown to increase the appearance of the renin-angiotensin system gene in the children. Conclusion: these results indicate targets for the interaction of environmental genes in various conditions of hypertension and essential hypertension.

Latar Belakang: Kanker serviks merupakan kanker dengan angka kejadian tertinggi ke-2 di Indonesia. Besarnya kasus kanker serviks yang ditemukan, mendorong pertanyaan, seberapa besar pemahaman masyarakat, terutama remaja mengenai kanker serviks. Tujuan: Mengetahui bagaimana tingkat pemahaman siswi SMAN 1 Sindang Indramayu mengenai kanker serviks dan faktor yang menyebabkannya. Metode: Penelitian ini menggunakan metode deskriptif dengan cara pengambilan data secara kuesioner online. Pengambilan data dilakukan pada bulan November- Desember tahun 2020, dengan jumlah sampel sebanyak 85 siswi. Hasil: Berdasarkan hasil penelitian, diketahui bahwa tingkat pemahaman siswi SMAN 1 Sindang Indramayu adalah cukup. Kesimpulan: Diperlukan tindak lanjut untuk mengatasi hal tersebut.