This is the first study to examine the involvement of ROCK gene variation in the risk of incident RDS. The results strongly suggest that ROCK gene polymorphisms may modify individual susceptibility to RDS in the Turkish population.

Neonates born to mothers with immune thrombocytopenia (ITP) have an increased risk for neonatal thrombocytopenia and hemorrhagic complications. The aim of this study was to determine the maternal and neonatal outcomes of pregnancies with ITP and also to identify risk factors that predicts neonatal thrombocytopenia. We performed a retrospective analysis of 40 pregnancies with ITP and their 40 neonates. Among the 40 neonates, thrombocytopenia (platelet count of less than 150 × 10/L) was detected in 15 neonates (37.5 %) whom 8 of them had severe thrombocytopenia (platelet count of less than 50 × 10/L). Ten of the 15 neonates with thrombocytopenia required treatment to increase the platelet counts. There was statistically significant association between neonatal thrombocytopenia and maternal splenectomy history and maternal duration of thrombocytopenia. There was no statistically significant correlation between maternal platelet count and neonatal platelet count. Clinicians should pay special attention in these neonates because of risk for development of neonatal thrombocytopenia. Maternal and neonatal outcomes in patients with idiopathic thrombocytopenic purpura is generally good.

The literature on neonates with SARS-CoV-2 is mainly concerned with perinatal cases, and scanty data are available about environmentally infected neonates. To fill knowledge gaps on the course and prognosis of neonatal cases, we analyzed 1-year data from the Turkish Neonatal Society in this prospective cohort study of neonates with postnatal transmission. Data from 44 neonatal intensive care units (NICUs), of neonates with positive RT-PCR results at days 5-28 of life, were extracted from the online registry system and analyzed. Of 176 cases, most were term infants with normal birth weight. Fever was the most common symptom (64.2%), followed by feeding intolerance (25.6%), and cough (21.6%). The median length of hospitalization was 9 days, with approximately one quarter of infants receiving some type of ventilatory support. Myocarditis (5.7%) was the most common complication during follow-up. Among the clinical findings, cough (odds ratio [

Split hand/foot malformation (SHFM), also known as ectrodactyly, is a congenital limb malformation characterized by a defect of the central rays of hands and/or feet due to the failure of ectodermal ridge activity. Split hand/foot malformation with long bone deficiency (SHFLD, OMIM 119100) is a rare condition and clinical manifestations are highly variable. SHFLD incidence is 1 in 1.000.000 live births. Here we report a premature newborn born at 33 gestational weeks with limb anomalies and diagnosed as split hand/foot malformation with tibial hypoplasia. With this case report, the importance of evaluating of patients with SHFLD for additional anomalies, estimating the appropriate time for limb salvage surgeries, achieving the best functional result with physiotherapy with multidisciplinary assessment was emphasized. Keywords: Ectrodactyly; split hand/foot malformation; tibial aplasia/hypoplasia Özet Yarık el/ayak malformasyonu (split hand/foot malformation, SHFM); ektrodaktili olarak da bilinen ve el ve/veya ayakta santral rayda yokluk nedeniyle parmak oluşum merkezindeki duraksama ile karakterize doğumsal bir ekstremite malformasyonudur. SHFM'nun uzun kemiklerde eksiklik ile giden tipi (split hand/foot malformation with long bone deficiency, SHFLD1, OMIM 119100) ise oldukça nadir görülür ve klinik olarak oldukça değişken görünümleri vardır. SHFLD insidansı 1/1.000.000 canlı doğumdur. Bu yazıda ekstremite anomalileri ile doğan ve tibia hipoplazisinin eşlik ettiği split el/ayak malformasyonu tanısı konan 33 haftalık bir yenidoğan sunuldu. Bu olgu nedeniyle de SHFLD tanılı hastaların multidisipliner değerlendirilme ile ek anomaliler açısından taranması ve uygun zamanda ekstremite koruyucu cerrahiler ve fizik tedavi ile en iyi fonksiyonel sonucun kazandırılmasının önemi vurgulandı. Anahtar kelimeler: Ektrodaktili; yarık el/ayak malformasyonu; tibial aplazi/hipoplazi Giriş Yarık el/ayak malformasyonu (split hand/foot malformation, SHFM); ektrodaktili olarak da bilinen ve el ve/veya ayakta santral rayda yokluk nedeniyle parmak oluşum merkezindeki duraksama ile karakterize doğumsal bir ekstremite malformasyonudur (1). Etkilenen ekstremitede medial yarıklar, sindaktili ve diğer fenotipik anomaliler ile genellikle ilişkili bulunan falanks, metakarp ve metatarslardaki aplazi veya hipoplazi ile kendini gösterir. Sıklığı yaklaşık olarak 1/18000'dir. Yarık el/ayak malformasyonları izole olarak görülebileceği gibi ektrodaktili, ektodermal displazi, yarık damak/dudak sendromu (EEC sendromu) ve ektrodaktili, ektodermal displazi, maküler distrofi sendromu (EEM sendromu) gibi sendromlara da eşlik edebilir (2). Aynı zamanda tibia hipoplazisine en sık eşlik eden defekt de split el/ayak malformasyonudur (OMIM 275220).

Objective Sepsis diagnosis is challenging due to nonspecific symptomatology in newborns. Timely diagnosis is essential for reducing sepsis-related morbidity and mortality. This study was performed to determine the diagnostic value of the delta neutrophil index (DNI) for detection of neonatal sepsis and to compare its efficacy with other conventional markers. Methods This study was conducted at a tertiary hospital in newborns with confirmed sepsis (n = 59), suspected sepsis (n = 46), and in age- and weight-matched controls (n = 49). DNI, white blood cell count, C-reactive protein (CRP) level, and platelet measurements were determined, and blood cultures were performed at the onset of symptoms. Results The mean DNI was significantly higher in confirmed and clinical sepsis groups compared with the control group. (6.9 ± 9.3, 1.9 ± 2.1, and 0.4 ± 0.5, respectively, p < 0.001). ROC curve analysis also showed that the combination of DNI and CRP had the highest sensitivity (86%), specificity (100%), and positive predictive value (100%) for predicting neonatal sepsis. DNI values were significantly higher in nonsurvivors (p < 0.05). Conclusion DNI could be used as a reliable diagnostic marker for neonatal sepsis, and high DNI could predict sepsis development and unfavorable outcomes. The diagnostic capability of DNI may be increased by assessing CRP measurements simultaneously.