No abstract

PATHOGENETIC ROLE OF METABOLIC DISORDERS IN CHILDREN WITH NEPHROLITHIASIS 812 children with nephrolithiasis were examined. Metabolism disorders were defined including, hypercalciuria and hypernatriuria in 37.3+2.4% of children, calciuria-in 62.5+5.3%, phosphaturia-in 26.6+2.5%, hyperoxaluria-in 83.1+1.76%, hand hyperuricosuria-in 51.7+4.7% have been fixed in 812 children with nephrolithiasis. In 80% events kidney stones contained 63-84% urinal calcium and oxalate acids. The study has revealed that kidney H+ secretion was decreased in all patients with nephrolithiasis accompanied with metabolic acidosis. The study has made possible to describe state of metabolism in patients with nephrolithiasis, define the occurrence frequency of the main metabolic disorders, and evaluate the importance of the specific biochemical investigations of this disease.