Latar belakang. Terapi yang adekuat pada hiperplasia adrenal kongenital (HAK) diharapkan dapat menghasilkan perkembangan pubertas dan pertumbuhan linear yang optimal. Saat ini, di Indonesia, belum ada data profil pubertas dan pertumbuhan linear penderita HAK yang sedang menjalani terapi. Tujuan. Mengetahui profil pubertas dan pertumbuhan linear pada HAK di Indonesia yang sedang menjalani terapi. Metode. Studi serial kasus terhadap 14 kasus HAK yang memasuki masa pubertas di Departemen Ilmu Kesehatan Anak Rumah Sakit Cipto Mangunkusumo Jakarta selama bulan November 2012 hingga April 2013. Pencatatan data berisi anamnesis, pemeriksaan fisis, pemeriksaan laboratorium, dan radiologi bone age. Hasil. Hasil penelitian ini merupakan riset pendahuluan (preliminary research) terhadap 14 kasus HAK. Mayoritas subjek adalah perempuan, berusia di atas 8 tahun, HAK tipe Salt-Wasting (SW), dan terdiagnosis sejak kurang dari satu tahun. Tujuh dari 14 subjek mengalami obesitas. Undertreatment terjadi pada 11/14 subjek memiliki bone age accelerated dengan perhitungan tinggi badan dewasa yang pendek. Tiga belas subjek sudah pubertas dan 10/14 subjek mengalami pubertas prekoks. Rekomendasi dosis glukokortikoid yang diberikan (median 18,12 mg/m 2 /hari) dengan median durasi terapi 8,1 tahun. Kontrol metabolik dengan menggunakan parameter 17-OHP bervariasi pada rentang 0,2-876 nmol/L (rerata 166,9 nmol/L). Kesimpulan. Sebagian besar subjek mendapatkan undertreatment sehingga memiliki bone age accelerated dengan estimasi tinggi badan dewasa pendek. Pubertas prekoks dialami oleh sebagian besar subjek. Pemberian glukokortikoid dengan dosis yang direkomendasikan. Ditemukan ketidakteraturan pengobatan dan pemantauan yang buruk. Sari Pediatri 2015;16(5):356-64.Kata kunci: hiperplasia adrenal kongenital, pubertas, pertumbuhan linear, terapi
“GB” Field is a gold mineral prospect field located in Jambi, Indonesia. The gold zone is identified using 3D inversion magnetic data. The types of mineralization in this area are high epithermal sulfidation and porphyry copper-gold, which were formed in a hydrothermal environment. Characteristic of this type is a host rock of intermediate-acid igneous rock. This rock comprises mineral ores such as copper-gold and magnetic gangue minerals. Therefore, magnetic methods are very sensitive in identifying the gold prospect areas. Magnetic data were acquired at a 5 m spacing between stations along 51 lines with 100 m spacing between lines. To identify the position, type, and depth of the subsurface structure relating to the gold deposition environment, derivative analysis was performed using first horizontal derivative and Euler deconvolution calculations. Then, a 3D inversion model is constructed to objectively delineate the subsurface structure. Induced polarization as well as geological data are also used to identify the resistivity and chargeability parameters of the prospect zone and its environment. Thus, a gold deposition zone was identified based on the lithocap and intrusion body. The top of the intrusion rock was at a depth of 80 m from the surface.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.