No abstract

Abstract. Engineered advanced functional materials are promising candidates for biotechnology and biomedical science. Mg-Al layered double hydroxide (LDH), anionic or hydrotalcite-like clays consist of positively charged layers and exchangeable anions along with water molecules in the interlayer space were synthesized from homogeneous solution of MgCl 2 and AlCl 3 by urea induced co-precipitation method. A pharmaceutically important drug, cephradine was intercalated with synthesized LDH in alkali media (pH 10) by in-situ technique. Characterizations of the products were carried out using Attenuated Total Reflectance Infra-red (ATR-IR), Energy Dispersive X-ray (EDX) and X-ray Diffraction (XRD) spectroscopy. Scanning electron morphological images envisaged a distinct crystalline and amorphous phases of Mg-Al LDH before and after modification with cephradine. Intercalation of bioactive molecules with LDH would enhance their stability providing sustained release behavior in physiological environment.

No abstract

Engineered advanced functional materials are promising candidates for biotechnology and biomedical science. Mg-Al layered double hydroxide (LDH), anionic or hydrotalcite-like clays consist of positively charged layers and exchangeable anions along with water molecules in the interlayer space were synthesized from homogeneous solution of MgCl2 and AlCl3 by urea induced co-precipitation method. A pharmaceutically important drug, cephradine was intercalated with synthesized LDH in alkali media (pH 10) by in-situ technique. Characterizations of the products were carried out using Attenuated Total Reflectance Infra-red (ATR-IR), Energy Dispersive X-ray (EDX) and X-ray Diffraction (XRD) spectroscopy. Scanning electron morphological images envisaged a distinct crystalline and amorphous phases of Mg-Al LDH before and after modification with cephradine. Intercalation of bioactive molecules with LDH would enhance their stability providing sustained release behavior in physiological environment.

Abstract. Naturally engineered cellulosic fibres are of particular interest due to their diverse interfacial behavior; which could be well suited to operating interaction with functionalized drug. In the present work, interaction of Lidocaine (LC) hydrochloride, 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide was widely studied with cellulosic fibres i.e. cotton, jute and coir in presence of 0.1M HCl aqueous solution. In UV-Vis spectroscopy measurement, it is revealed that the highest interaction (adsorption 18 mg/g of fibres) of LC was occurred onto the cotton fibres surfaces from 3.5 mg/mL aqueous solution after 30 minutes gentle shaking. Kinetic studies in case of cotton fibres showed a linear relationship (R 2 = 0.9987) during desorption of LC upto 30 minutes at 25 o C temperature. The cotton fibres concentration was to be calculated 0.0085 g unit mol/L by considering the unit molecular weight of glucose unit. When 2.5 mg/mL (0.0108 g mol/L) LC drug solution was used then the ratio between glucose unit and LC drug was found to be 1.27. The interaction of LC was also increased direct-proportionally to the weight of cotton fibres. The resulting interaction phenomena of model LC would help us to deign dosage of anesthetic drug for specific physiological conditions.