We might suggest that the elevated levels of TGF-beta2 in the aqueous of glaucoma patients could play a role in the pathogenesis of glaucoma.

Ropivacaine used in peribulbar block is better than bupivacaine-lidocaine mixture under the same standard conditions in terms of reducing intraocular pressure and postoperative pain in intraocular surgery.

In the present study the effects of β-adrenergic antagonist and α-adrenergic agonist drugs on rabbit corneas were evaluated in vivo by using transmission electron microscopy. Twenty-four New Zealand albino rabbits were divided into six groups according to the drug applied. The rabbits to which only balanced salt solution (BSS) or BSS and benzalkonium chloride (BAC) were applied were taken as the control groups. The other four groups consisted of the rabbits to which Timoptic 0.5%, Betagan 0.5%, Betoptic 0.5% and Iopidine 1% were applied, respectively. All of drugs were instilled topically twice daily for 6 weeks. In the BSS group, all layers of the cornea were ultrastructurally normal. In the BSS and BAC group slight epithelial and endothelial changes were found. However, in the other groups, loss of microvilli, increase in glycogen particles, nuclear indentation, widening of the intercellular spaces and cytoplasmic vacuolization in epithelium were observed. No significant abnormality was found in the basal lamina, stroma and Descemet’s membrane. Slight ultrastructural changes were noted in the endothelium such as vacuolization due to dilatation of the endoplasmic reticulum cisternae and focal cytoplasmic lytic areas. The results of this study indicate that various ultrastructural changes occur in groups treated with antiglaucomatous drug and that topical treatment with timolol and apraclonidine for 6 weeks is more toxic to the rabbit cornea than levobunolol and betaxolol.

In this study, we aimed to show changes of central corneal thickness and effects of treatment on visual acuity after corneal collagen cross-linking in keratoconus patients. Materials and Methods: 26 eyes of 51 patients with keratoconus who undergone corneal collagen cross-linking were included in to the study. Central corneal thickness measurements and best corrected visual acuity were recorded before and after 1 st and 6 th month of corneal collagen cross-linking operation. Results: Mean central corneal thickness measurements were recorded as; 435,43±44,35 μm, 376,68±66,55 μm and 392,62±64,21 μm before and after 1 st and 6 th month of corneal collagen cross-linking, respectively. There was a statistically significant difference between pre-op and postop 1 st month, pre-op and postop 6 th month and postop 1 st month and post-op 6 th month central corneal thickness measurements. Also, there was a statistically significant increase in best corrected visual acuity after the operation. Conclusion:There was a statistically significant difference between pre-op, post-op 1 st month and postop 6 th month central corneal thickness and best corrected visual acuity measurements. Amaç: Bu çalışmada, keratokonus hastalarında korneal kollajen çapraz bağlama tedavisinin görme keskinliği ve merkezi kornea kalınlığına etkilerinin gösterilmesi amaçlanmıştır. Gereç ve Yöntem: Korneal kollajen çapraz bağlama işlemi uygulanan 26 hastanın 51 gözü çalışmaya dahil edildi. Merkezi kornea kalınlık ölçümleri ve en iyi düzeltilmiş görme keskinlikleri işlemden önce ve sonrasındaki 1. ay ve 6. ayda kayıt altına alındı. Bulgular: Ortalama merkezi kornea kalınlık ölçümleri işlem öncesi, işlem sonrası 1. ay ve işlem sonrası 6.ay olmak üzere sırasıyla 435,43±44,35μm, 376,68±66,55μm ve 392,62±64,21 μm olarak kaydedildi. İşlem öncesi ve işlem sonrası 1. ay, işlem öncesi ve işlem sonrası 6.ay ve işlem sonrası 1. ay ve işlem sonrası 6.ay merkezi kornea kalınlığı ölçümleri arasında istatistiksel olarak anlamlı fark bulundu. Aynı zamanda, işlem sonrası görme keskinliği artışı istatistiksel olarak anlamlı bulundu. Sonuç: İşlem öncesi, işlem sonrası 1.ay ve işlem sonrası 6. ay merkezi kornea kalınlık ölçümleri ve en iyi düzeltilmiş görme keskinliği ölçümlerinde istatistiksel olarak anlamlı değişiklikler bulundu.

No abstract