Aim: To assess CML patient's characteristic including demographic, clinical and hematological characteristic of patients with CML including quantitative BCR-ABL and BCR-ABL gene sequencing. Methods: This study was an open-label, single arm, non-randomized, cross sectional study in patients with CML being treated with imatinib mesylate (IM) from 12 centers. Result: A total of 100 patients were evaluated between January 1, 2009 and December 31, 2011. The median age was 34-35 years old (mean of age is 36 years old), and more patients in the productive age was found.-(?) were 80 of the 100 patients who had been examined for the BCR-ABL gene mutation with the sequencing method before consuming IM. Mutation in the P-loop was seen in 2,27% (1 out of 44 patients), this finding was beyond our expectation since 47,69% (31 out of 65 patients) of our patients did not achieved CHR at three months. On the other hand, 15,9% (7 out of 44 patients) of our patients had mutation outside the P-loop. Conclusions: The characteristics of CML patients in Indonesia were not different from CML patients in Asia in general. Our finding concerning the high frequency mutation in the BCR-ABL gene outside the P-loop needs further study.

Abstract. Dengue Hemorrhagic Fever (DHF) is a public health problem in Indonesia with many endemic areas and an increasing number of sufferers and a wider spread, and in 2016 West Java became one of the areas with the highest average dengue cases each year. The purpose of this study was to determine the pattern of platelet and hematocrit levels of DHF sufferers in the Internal Medicine Ward at Al-Ihsan Hospital, Bandung in January-December 2021. The research method used was an observational descriptive study with the cross-sectional research design. The data collection technique uses total sampling derived from primary medical record data. The results showed that in 202 DHF patients, the highest pattern of platelet decrease occurred on the 2nd day and began to increase on the 3rd day. Meanwhile, the hematocrit experienced the highest pattern of increase on day 1 and decreased on day 3. The conclusion of this study is that the platelet count in DHF patients tends to increase again on the 3rd day during hospitalization as well as the hematocrit level which tends to decrease again on the 3rd day. The weakness of this study is that the researchers do not know and examine patterns of fever and illness in DHF patients before receiving treatment at the hospital. Abstrak. Demam Berdarah Dengue (DBD) menjadi satu persoalan kesehatan masyarakat di Indonesia dengan banyak daerah yang endemik dan jumlah penderita yang semakin banyak serta penyebarannya semakin luas dan  pada 2016 Jawa Barat menjadi salah satu daerah dengan rata-rata kasus DBD tertinggi setiap tahunnya. Tujuan penelitian ini adalah untuk mengetahui pola kadar trombosit dan hematokrit penderita DBD di Bangsal Penyakit Dalam RSUD Al-Ihsan Bandung pada bulan Januari–Desember 2021. Metode penelitian yang digunakan adalah penelitian deskriptif observasional dengan desain penelitian cross sectional. Teknik pengambilan data menggunakan total sampling yang berasal dari data primer rekam medis. Hasil penelitian menunjukkan pada 202 pasien DBD terjadi pola penurunan trombosit terbanyak pada hari ke-2 dan mulai meningkat pada hari ke-3. Sedangkan untuk hematokrit mengalami pola peningkatan terbanyak pada hari ke-1 dan penurunan pada hari ke-3. Kesimpulan dari penelitian ini adalah gambaran trombosit pada penderita DBD cenderung meningkat kembali pada hari ke-3 saat rawat inap begitu juga dengan  kadar hematokrit yang cenderung menurun kembali pada hari ke-3. Kelemahan dari penelitian ini yaitu tidak mengetahui dan meneliti pola demam dan sakit pada pasien DBD sebelum pasien mendapatkan perawatan di Rumah Sakit.

Abstract. Stress is a body's reaction to changes that require physical, psychological, and emotional responses, regulation, and/or adaptation. Stress can come from situations, thoughts, and any circumstances that can cause frustration, nervousness, and anxiety. The purpose of this study was to determine the relationship that occurs with stress levels and graduation in high school students. It can also be seen that UTBK can be one of the triggers of stress which can affect a third-grade high school student in preparing for UTBK and can result in a decrease in concentration. This can have an impact on the graduation rate of admission to public universities. This research is a analitic observational study with a cohort design method. The sample for this study used a stratified random sampling technique, totaling 66 third-grade students and the respondents were taken using the sample size formula, obtaining a minimum of 58 third-grade students. The data for this study were taken from primary data which was filled out in the Google form and from secondary data which was the UTBK graduation announcement from the third-grade students of the relevant high school. The results of the research obtained were based on conducting a chi-square test so that a value of 0.485 (p> 0.05) was obtained, which means that there was no relationship between the level of stress before UTBK and the graduation rate of state universities in-class students. Abstrak. Stress adalah Suatu reaksi tubuh terhadap perubahan yang memerlukan respon, regulasi dan atau adaptasi fisik, psikologis dan emosional. Stres dapat besumber dari situasi, pemikiran dan keadaan apapun yang dapat menyebabkan frustasi, kegugupan dan kecemasan. Tujuan dari penelitian ini ialah untuk mengetahui hubungan yang terjadi terhadap tingkat stress dengan kelulusan pada siswa SMA. Dapat diketahui juga UTBK bisa saja menjadi salah satu pemicu dari stress yang dapat memengaruhi dari seorang murid kelas tiga SMA dalam mempersiapkan diri untuk menghadapi UTBK dan dapat mengakibatkan penurunan konsentrasi. Hal ini dapat berdampak kepada tingkat kelulusan masuk ke perguruan tinggi negeri. Penelitian ini rupakan penelitian observasional analitik dengan metode desain cohort. Pengambilan sampel penelitian ini menggunakan tektik stratified random sampling yang berjumlah 66 murid kelas tiga dan dilakukan perhidungan responden dengan rumus sample size, didapatkan minimal responden 58 murid kelas tiga. Data penelitian ini diambil dari data primer yang dilakukan pengisian google form dan dari data sekunder yang merupakan pengumuman kelulusan UTBK dari murid kelas tiga SMA terkait. Hasil dari penelitian yang didapatkan berdasarkan dengan melakukan uji chi-square sehingga, didapatkan nilai 0,485 (p>0,05) yang berarti tidak ada hubungan antara tingkat stress sebelum UTBK dan tingkat kelulusan perguruan tinggi negeri pada murid kelas.

Hipertensi adalah peningkatan tekanan darah sistole ≥140 mmHg dan diastole ≥90 mmHg, diukur dua kali, selang waktu lima menit dalam keadaan tenang. Prevalensi hipertensi di Indonesia tahun 2013 tercatat 25,8% dan menjadi 34,1% pada 2018. Pengobatan hipertensi selain menggunakan obat, dapat diberi terapi non-farmakologis, salah satunya adalah terapi musik. Tujuan penelitian ini menganalisis efek musik sebagai terapi tambahan terhadap pengendalian tekanan darah pada penderita hipertensi. Penelitian ini merupakan Scoping Review, dengan mencari artikel dari database Science Direct, Neliti, dan DOAJ diperoleh 2.784 artikel. Hasil skrining yang sesuai kriteria inklusi sebanyak 474 artikel. Hasil uji kelayakan berdasar atas PICOS dan setelah dilakukan telaah kritis terdapat enam artikel yang memenuhi syarat. Penelitian dilakukan pada periode September–Desember 2020. Hasil telaah dan analisis dari enam artikel menyatakan pemberian musik selama 15–25 menit memengaruhi tekanan darah dan terdapat perbedaan tekanan darah sebelum dengan setelah diberikan musik pada penderita hipertensi. Selain itu, lima artikel menyatakan terdapat perbedaan tekanan darah pada penderita hipertensi yang tidak diberikan terapi musik. Tiga artikel menyatakan terdapat perbedaan efek penurunan tekanan darah antara kelompok intervensi musik dan kelompok yang tidak diberikan intervensi musik. Alunan musik dapat menstimulasi tubuh mengeluarkan molekul nitric oxide yang menyebabkan pelebaran pembuluh darah sehingga dapat menurunkan tekanan darah. Kesimpulan penelitian ini adalah pemberian terapi musik efektif terhadap pengendalian tekanan darah pada penderita hipertensi. Scoping Review: Music Effects as Additional Therapy on Controlling Blood Pressure in Hypertensive PatientsHypertension was an increase in systolic blood pressure ≥140 mmHg and diastolic ≥90 mmHg, measured twice, five minutes apart in a calm state. The prevalence of hypertension in Indonesia in 2013 was recorded at 25.8% and became 34.1% in 2018. Treatment of hypertension in addition to using drugs, can be given non-pharmacological therapy, which is music therapy. The purpose of this study was to analyze the effect of music as an additional therapy on controlling blood pressure in hypertensive patients. This research is a Scoping Review, by searching articles from the database Science Direct, Neliti, and DOAJ obtained 2,784 articles. The screening results that matched the inclusion criteria were 474 articles. The results of the feasibility test were based on PICOS and after a critical review there were six articles that met the requirements. The research was conducted in the period September–December 2020. The results of the study and analysis of six articles stated that giving music for 15–25 minutes affected blood pressure and there were differences in blood pressure before and after being given music to people with hypertension. In addition, five articles stated that there were differences in blood pressure in hypertensive patients who were not given music therapy. Three articles stated that there were differences in the effect of lowering blood pressure between the music intervention group and the group that was not given music intervention. The music can stimulate body to release nitric oxide molecules which cause blood vessels to dilate so that can lower blood pressure. The conclusion of this study is that music therapy is effective in controlling blood pressure in hypertensive patients.