Neonatal abnormal noxious and tactile stimulations facilitate the activity of spinal neurons, which leads to an altered somatosensory and pain phenotype in adulthood.

Paracetamol can be used safely in neonatal rats. Neonatal paracetamol treatment had no effect upon short-term mechanical hypersensitivity during the first postnatal week, nor upon long-term baseline sensitivity from 3 to 8 weeks. Paracetamol treatment during the first postnatal week significantly reduced the postoperative mechanical hypersensitivity in young adult rats.

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