This study investigated poultry farmers' perceptions, preferences, and use of commercially compounded and self-compounded feeds in the Oyo Area of Oyo State, Nigeria. Data were collected from 120 poultry farmers through a structured interview schedule. The study concluded that poultry farmers prefer and use self-compounded feeds (SCF) instead of commercially compounded feeds (CCF) because (a) self-compounded feeds are of better quality than commercially compounded feeds, (b) there are no quality control measures in the poultry feed industry in the Oyo Area, (c) commercially compounded feeds cost more than self-compounded feeds, and (d) farmers choose feed based on the perceived quality of the feed, their technical ability to produce feed by themselves, the cost of CCF, the storability of feed, and the cost and availability of transportation. Based on these findings, it is recommended that interested public and private agencies should organize annual extension workshops and training for poultry farmers in the study area on (a) feed formulation; (b) feed ingredient mixing and compounding; (c) selection of ingredients, mixtures, and additives; and (d) the establishment, operation, and maintenance of feed mills. Farmers should be encouraged to form feed mill cooperative societies. The performance of the Standards Organization of Nigeria (SON) should be monitored and evaluated to ensure its effective oversight of quality standards for agricultural products and inputs such as feeds and feed ingredients.