The NF-U UB transcriptional factor regulates various functions such as immune responses, cellular growth and development, and is frequently activated in tumor cells. Thus, inhibition of NF-U UB could suppress tumor cell growth. Using a decoy synthetic hairpin-shaped oligodeoxyribonucleotide (ODN) containing the U UB site with an integrated single diphosphoryldisul¢de linkage, we demonstrate its covalent binding to the p50 subunit of NF-U UB. Furthermore, this decoy ODN induces apoptosis in a lymphoblastoma cell line. Thus, such chemically modi¢ed decoys could be valuable tools for blocking nuclear factors and tumor cell growth.

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