Cucurbits are group of plants which belonged in the Cucurbitaceae family and constitute one of the most important vegetables for human consumption throughout the world. A survey conducted between January to March 2021 across major cucurbit-growing area in Cross River State revealed wide spread virus infection of these crops, surveyed plants showed mosaic, mottle and leaf deformation symptoms. This research was aimed at identifying viruses infecting some cucurbits in the study areas. Twenty four samples showing virus like symptoms were collected and tested against ACP-ELISA and RT-PCR. Result obtained from ACP-ELISA showed that 20 out of 24 samples collected tested positive to universal potyvirus antisera, the gene sequence analysis revealed that samples were predominantly infected with Algerian watermelon mosaic virus representing 40% of total viruses detected followed by Morroccan watermelon mosaic virus representing 15% of total viruses detected followed by Papaya ringspot virus, Zucchini tigre mosaic virus, Watermelon mosaic virus and Soybean mosaic virus representing 10% each for total viruses detected and finally Potato virus Y representing 5% of total virus detected. This survey is an accurate and timely detection and will form the basis for mitigating yield losses resulting from virus infection on cucurbits. This is the first report of wide scale detection of viruses infecting cucurbits in Nigeria.