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URL: http://www.clinicaltrials.gov. Unique identifier: NCT01994720.

Background and objectives. Stroke-induced mortality is the third most common cause of death in developed countries. Intense interest has focused on the recurrent ischemic stroke, which rate makes up 30% during first 5 years after first-ever stroke. This work aims to develop criteria for the prediction of acute recurrent cerebral ischemic hemispheric stroke (RCIHS) outcome on the basis of comprehensive baseline clinical, laboratory, and neuroimaging examinations. Materials and Methods. One hundred thirty-six patients (71 males and 65 females, median age 74 (65; 78)) with acute RCIHS were enrolled in the study. All patients underwent a detailed clinical and neurological examination using National Institutes of Health Stroke Scale (NIHSS), computed tomography of the brain, hematological, and biochemical investigations. In order to detect the dependent and independent risk factors of the lethal outcome of the acute period of RCIHS, univariable and multivariable regression analysis were conducted. A receiver operating characteristic (ROC) analysis with the calculation of sensitivity and specificity was performed to determine the prediction variables. Results. Twenty-five patients died. The independent predictors of the lethal outcome of acute RCIHS were: Baseline NIHSS score (OR 95% CІ 1.33 (1.08–1.64), p = 0.0003), septum pellucidum displacement (OR 95% CI 1.53 (1.17–2.00), p = 0.0021), glucose serum level (OR 95% CI 1.28 (1.09–1.50), p = 0.0022), neutrophil-to-lymphocyte ratio (OR 95% CI 1.11 (1.00–1.21), p = 0.0303). The mathematical model, which included these variables was developed and it could determine the prognosis of lethal outcome of the acute RCIHS with an accuracy of 86.8% (AUC = 0.88 ± 0.04 (0.88–0.93), p < 0.0001).

The aim of the work – to improve the professional training of students by forming the skills of independent educational and research work. The main body. Nowadays, study work of students takes an important place in the educational process. A lot of difficulties among the students appear during the process of enquiring the skills of independent work; in many cases they are connected with the issues of methodological nature. So, the teacher’s task is to help students in choosing the topic, setting the goal and tasks of the study, and also to determine the scale, materials and methods of the research. Doing some kind of educational and research work under the guidance of the teacher expands students’ scientific outlook and enables them to master the essential scientific concepts and understandings. Conclusion. In the process of writing research work students develop their skills to analyze, systematize, compare, generalize and classify scientific literature data and also obtained results of the conducted research.

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