The objective: to determine the optimal prophylactic and therapeutic drug to support and restore the biphasic menstrual cycle against the background of the influence of chronic stress. Materials and methods. A comparative study of the effectiveness of the use of preparations of dry extract of common rod (Vitex Agnus castus ) BNO 1095 and various vitamin complexes with a sedative effect, which contain vitamins of group B, magnesium, folic acid, herbal preparations of valerian, pasiflora, was carried out. The hormonal profile and psychoemotional state in women with dyshormonal disorders in modern conditions were studied. Results. The clinical efficacy and feasibility of using the drug Vitex Agnus castus in women with dyshormonal disorders in conditions of psychoemotional disadaptation due to the harmonizing effect on the concentration of female sex hormones, normalizing the ratio of gonadotropic hormones, eliminating the estradiol / progesterone imbalance against the background of a decrease in prolactin level has been proven. Conclusion. The presented results of the study prove the effectiveness of the use of the phytopreparation Vitex Agnus castus in women with dyshormonal disorders under conditions of chronic stress due to its dopaminergic effect on psychoemotional status as a result of elimination of latent stress-induced hyperprolactinemia, comparable to the effect of synthetic inhibitors of prolactin secretion. In addition, the drug Vitex Agnus castus can be prescribed to prevent the occurrence of phase inconsistency in the secretion of gonadotropic hormones due to the activation of stress-limiting systems and local neuroendocrine modulators, which helps to reduce stress stress. Keywords: dyshormonal disorders, chronic stress, maladjustment.