No abstract

LOD score of 2.09. Objective(s): To further map the gene(s) that is responsible for the LOD peak in this region of the chromosome 8, using variance-component procedure in SOLAR with increased sample size, and using Illumina Goldengate genotyping method. Methods: We genotyped four micro-satellite markers under this linkage region using additional 158 families with the same linkage analysis as in our previous study. We then followed up a 1-LOD score down region from the linkage peak using high density SNPs by genotyping 1536 Illumina Goldengate SNPs for association study to fine map the region. Results: We obtained an updated two-point LOD score of 2.34 at the marker D8S1179. In addition, the new analysis narrowed the peak region to about 20cM (between 128 to149cM; LODϾ1.0). We are currently genotyping 1536 Illumina Goldengate SNP OPA to follow up the ϳ24mb area between q23.3 to q24.23 in Chr8 under the new linkage peak. Conclusions: These data strengthen the evidence for a potential gene(s) in this region contributing to the genetic etiology of AAO in AD.