Absolute configuration of ro-phenyl-2-alkylamines Ia -Ic (R = H) and their N-methyl derivatives la-Ie (R = CH 3 ) has been determined by the method of the asymmetric transformation and analysis of ORD curves. In the case of the amine Ic (R = H) also the chemical corr.elation has been used.In connection with the use of the asymmetric transformation in determining the absolute configuration of organic compounds 1 -3, the absolute configuration of co-phenyl-2-alkylamines la-Ie (R = H) and their N-methyl derivatives la-Ie (R = CH 3 ) has been determined. In molecules of these amines, the aromatic ring is separated in a various distance from the asymmetric carbon atom by a saturated chain. It was therefore of interest to measure the 0 RD curves of these compounds and to determine the influence of the aromatic chromophore on the shape and sign of the Cotton effect while the absolute configuration is equal.

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S)-y-Butyrolactone-y-carboxylic acid (III, R = H) (levorotatory in water, dextrorotatory in methanol), in form of its methyl ester III (R = CH 3 ), was reduced to (S)-( -)-1,2,5-pentanetriol (IV) the absolute configuration of which was determined by correlation with (R)-( + )-glycerraldehyde. The probable absolute configuration of (R)-y-valerolactone-y-carboxylic acid (VII, R = H) (dextrorotatory in ' water; levorotatory in methanol) has been derived by comparing ORD curves of the both acids studied, and their derivatives.

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