Objective. One of the most common gynecological pathologies among women of reproductive age is non-specific vaginitis. Bacterial vaginosis and aerobic vaginitis cause many obstetric and gynecological complications, and disease recurrence remains high. The aim of the study is to assess the effectiveness of complex therapy in the treatment of non-specific vaginitis in women of reproductive age. Materials and Methods. 160 women (100%) were examined, which were divided into 2 clinical groups with subgroups: the main group - 94 (58.8 %) patients with nonspecific vaginitis, who received treatment according to developed clinical diagnostic algorithms and schemes. The comparison group included 66 (41.2 %) patients with nonspecific vaginitis, who received treatment according to known protocols. Research methods: general (collection of complaints and anamnesis, gynecological examination, assessment of microscopy of vaginal smears according to the Amsel, Nugent and Donders criteria), laboratory (determination levels of follicle-stimulating, luteinizing hormones, prolactin, estradiol, adrenaline, noradrenaline, cortisol, magnesium in the blood), statistical. Results. Treatment of non-specific vaginitis according to complex schemes in the main group showed a significant decrease in the average follicle-stimulating hormone indicators – by 2.7 times, luteinizing hormone – by 2.6 times, prolactin – by 1.3 times (р<0,05) compares to the indicators before treatment. The estradiol level in the main group probably increased 1.3 times (р<0,05). The magnesium level also increased by an average of 1.4 times (р<0,05). Complex therapy in the main group significantly reduced the adrenaline levels by an average of 1.6 times, noradrenaline by 2.4 times, and cortisol by 1.8 times compared to the values before treatment (р<0,05). The proposed complex schemes are likely to improve the clinical effectiveness of drug treatment of non-specific vaginitis in the near and distant periods, which is accompanied by faster disappearance of complaints and normalization of the local condition during the gynecological examination (p<0,05), restoration of the vaginal microflora (p<0,05), a decrease frequency of recurrence in the main group of patients (c2=4,32; p<0,05). Conclusions. It is appropriate to use complex treatment of bacterial vaginosis and aerobic vaginitis in women of reproductive age.

Bacterial vaginosis and aerobic vaginitis are the most common problems among gynecological pathology in women of reproductive age. The share oh nonspecific vaginitis is affected by stress, which affects the state of a woman’s hormonal system. However, the relationship between hormonal changes, exposure to chronic stress and nonspecific vaginitis has not been fully estab­lished, which is up-to-date task. Aim of study is to study changes in the levels of gonadotropic and sex hormones, as well as cortisol in women of reproductive age with aerobic vaginitis and bacterial vaginosis. 160 women (100%), divided into 2 clinical groups with subgroups were examined: the main group – 94 (58.8 %) patients with nonspecific vaginitis, who received treatment according to developed clinical diagnostic algorithms and schemes. The comparison group included 66 (41.2%) patients with nonspecific vaginitis, who received treatment according to known protocols. In the process of examining groups, the following research methods were used: general (collection of complaints and anamnesis, gyneco­logical examination, assessment of microscopy of vaginal smears according to the Amsel, Nugent and Donders criteria), laboratory (method of determining the level of follicle-stimulating hormone, luteinizing hormone, prolactin, estradiol, cor­tisol), statistical. According to the study results it was found that women of reproductive age with nonspecific vaginitis are likely to have elevated levels of follicle-stimulating, luteinizing hormones, prolactin, cortisol and significantly reduced estradiol levels compared to healthy individuals. In conclusion, the results indicate changes in gonadotropic and sex hor­mones in women with nonspecific vaginitis towards the increased levels of follicle-stimulating, luteinizing hormones, prolac­tin, cortisol and decreased levels of estradiol. Such hormonal changes indicate depletion of the hypothalamic-pituitary-genital system, which occurs under the influence of chronic stress on the body of women of reproductive age with nonspecific vaginitis.

Objective. To study the bacteriological composition and sensitivity of vaginal microflora and to optimize antibacterial therapy in women of reproductive age with aerobic vaginitis and bacterial vaginosis. Methods. 160 women (100%) were examined, which were divided into 2 clinical groups with subgroups: the main group - 94 (58,8 %) patients with nonspecific vaginitis, who received treatment according to developed clinical diagnostic algorithms and schemes. The comparison group included 66 (41,2 %) patients with nonspecific vaginitis, who received treatment according to known protocols. Methods: general clinical examination, gynecological examination, microscopic study (microscopy of vaginal smears according to the Amsel, Nugent and Donders criteria), bacteriological seeding and determination of the microflora’s sensitivity to antibacterial drugs on the automatic microbiological analyzer “VITEK 2” (France), statistical. Results. In women with AV the highest percentage of sensitivity of vaginal microflora was to moxifloxacin - 30,0 % and there were no resistant pathogens, in patients with BV – sensitivity to secnidazole was 86,3 %. After appropriate antibiotics were prescribed, a significant decrease was established in the main group of Escherichia coli (c2=7,23; P=0,008), Staphylococcus aureus (c2=3,87; P<0,049), Streptococcus agalactiae (c2=3,87; P<0,049) in AV, and a significant decrease of Gardnerella vaginalis (c2=28,20; P=0,001) і Atopobium vaginae (c2=3,87; P<0,049) in BV. Conclusion. Establishing the type of causative bacteria, its sensitivity to antibiotics and the appointment of rational antibacterial therapy are likely to improve clinical effectiveness in the near and long terms, reduce frequency of recurrence of nonspecific vaginitis.

Die Umsetzung der Schiffschen Basen (Ia) und (Ib) mit Diboran und die anschließende Abspaltung von Wasserstoff führt, wie bereits früher beschrieben (Zh.

Durch Anlagerung von Tetraäthyl‐diboran (II) an 3‐Methyl‐1,2‐butadien (I) entstehen hauptsächlich die Verbindungen (III) mit einer etwa 10%igen Beimen= a gung von (IV).