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Organo-silicon compoundsOrgano-silicon compounds S 0060 Synthesis and Cytotoxicity of 3-(Hetarylthio)-1-propynyl(trimethyl)silanes. -A novel two-step method for the synthesis of title silanes via phase-transfer catalyzed S-alkylation of corresponding heterocyclic thiols (I) with propargyl bromide followed by a silylation reaction is described. The biological activity of the compounds obtained is studied for two tumor cell lines (HT-1080 and MG-22A). Indole derivative (VII) displays the greatest cytotoxicity. -(ABELE, R.; ABELE, E.; RUBINA, K.; DZENITIS, O.; ARSENYAN, P.; SHESTAKOVA, I.; NESTEROVA, A.; DOMRACHEVA, I.; POPELIS, J.; GRINBERGA, S.; et al.; Chem. Heterocycl.

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Organic chemistryOrganic chemistry Z 0200 Indole and Isatin Oximes: Synthesis, Reactions, and Biological Activity. -[218 refs.]. -(ABELE, E.; ABELE, R.; DZENITIS, O.; LUKEVICS, E.; Chem. Heterocycl.