Investigation of the in vitro metabolism of 4,6dichloro-17a-hydroxypregna-4,6-diene-3,20-dione acetate (I) showed that in addition to the expected 4,6-dichloro-3hydroxy derivatives Ilia and IHb, the 6-monochloro compound II and the corresponding 6-monochloro-3-hydroxy compounds IVa and IVb were formed. Although proportions
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