From the standpoint of modern ideas, the normal functioning of the poultry body and full implementation her of the genetic potential is impossible without the presence of selenium in the diet. The biochemical diversity of selenium puts it in a number of priority trace elements. Scientists who were studying the effects of selenium on poultry body and paid relatively little attention to the quality of the meat. In scientific experiment are studied the effect of additives different doses of selenium in compound feed on the chemical composition, energy and biological value of meat of the cross chickens-broilers COBB 500. Introduction of selenium into the feed for broiler chickens in the doses which are studied (0.3 mg/kg, 0.4 and 0.5 mg/kg) did not significantly affect to the quality of their muscle tissue although it positively affected on some indicators that characterizing its chemical composition, nutritional and biological value. Among the experimental groups, the best meat quality indicators were in the second group of chickens for which was introduced into the feed selenium from the calculation of 0.3 mg/kg. When feeding mixed feeds with selenium additives to broiler chickens it was found that it is likely to increase the concentration of this trace element in muscle tissue by 60.6-100% (P?0.001), which does not exceed the maximum permissible level (MPL). Consumption of selenium-enriched meat of broiler chickens within the limits of the physiological norms recommended in Ukraine will ensure the daily requirement of an adult in this trace element by 23.6-29.4%. This meat product can be especially useful for people who live in regions with low levels of selenium in the natural environment.

The results of research of certain biochemical parameters of blood in dairy cows for the prevention of insufficiency of Co, Cu and Zn by inorganic and organic compounds of trace elements are presented. The purpose of the work – to investigate the state of individual biochemical parameters of blood in dairy cows when using inorganic and organic compounds Co, Cu and Zn to prevent their insufficiency. The research material was the blood serum of experimental animals, which determined the content of total protein and the percentage of albumin, total calcium content, inorganic phosphorus, aspartateaminotransferase (AST) activity, alanineaminotransferase (ALT), alkaline phosphatase (AP).For research on dairy cows of the first experimental group, together with the feeds of the main diet, a mixture of trace elements sulphates was fed in the following ratio of components (mg/100 kg body weight): CuSO4 – 50, CoSO4 – 5, ZnSO4 – 120. Animals of the second experimental group fed a mixture of methionates and lysinates of trace elements in the following ratio of components (mg/ 100 kg of body weight): CuMet – 15, CuLis – 15, CoMet – 1, CoLis – 1, ZnMet – 35, ZnLis – 35. Feeding the mixture of compounds of fragile microelements was carried out by mixing them with mixed fodder, once a day, for 60 days. The evaluation of the research results was carried out at the beginning and at the end of the experiment.On the background of the deficit of Сobalt, Сuprum and Zinc, clinically diseased animals have hypoproteinemia, hypoalbuminemia, hypocalcemia, increased activity of AST, ALT and AP, indicating a metabolic abnormality in cows and development of microelementosis. It was established that the use of chelated cheeses in the form of methionates and lysinates of scarce microelements had a better therapeutic effect compared to inorganic compounds. The result of the application of chelate compounds of trace elements was a possible increase in the content of total protein in the blood serum, fractions of albumins, total calcium, decrease in the activity of AST, ALT and AP.

In dairy farms of Ukraine, where highly productive dairy cows are kept, liver lesions are often diagnosed in the postpartum period. Postmortem studies of the liver of cows that were forcibly slaughtered showed that in mostly animals were diagnosed with fatty degeneration of the liver. The main causes of fatty hepatosis were violations of the structure of rations, imbalance of feeding on essential nutrients and biologically active substances, low content of easily digestible carbohydrates and high protein content. The study was performed on cows aged 4–5 years with productivity for the previous lactation of 5.600–7.500 L of milk, in a winter-stall period of keeping, 2–3 weeks after calving. According to clinical and biochemical blood tests, two groups of cows were formed – 50 clinically healthy and 50 cows with fatty liver disease. In cows diagnosed with fatty liver degeneration, the disease was manifested by decreased productivity and fatness, loss of appetite, oppression, hypotony of the rumen, reticulum and omasum. In some cows, there was pain at the liver area, increasing boundaries of hepatic dullness, jaundice of the visible mucous membranes and sclera. The blood serum of all cows with fatty liver disease established a decrease in albumin content, indicating impaired protein synthesis function of the liver. In some cows, the content of total protein in the serum increased due to globulin fractions, mainly gamma globulins. The ratio between the content of albumins and globulins decreased, which indicates the development in the blood of sick animals dysproteinemia. The development of fatty infiltration of the liver caused an increase in the concentration of bile acids in the serum of all sick cows. This is due to reduced conjugation and excretion of cholates by affected hepatocytes from the bile capillaries. The formation, absorption, conjugation, and excretion of bilirubin in the bile is disturbed, which causes the accumulation of total and conjugated bilirubin in the serum of sick animals. The cholesterol content in the blood of cows decreased, caused a violation of the esterification of its esters by hepatocytes. The established changes in the content of bile acids, total and conjugated bilirubin, and cholesterol in the blood of sick cows indicate a violation of bile secretion, bile production, and cholestasis development. In some cows with fatty liver degeneration, urea formation function and carbohydrate function are impaired, leading to a decrease in blood urea content and glucose.

1536 Background: The use of oncology hospitalists has been shown to improve quality outcomes among hospitalized patients, though there is limited data on the use of hospitalists to care for patients with hematologic malignancies. The Hematology Malignancy Hospitalist Service (HMHS) was created in efforts to decrease patient volume on the primary hematology malignancy services at an academic hospital. Patients with active oncologic issues requiring specialty oncology management were cared for by oncologists on the primary leukemia, lymphoma, and myeloma services while patients with acute medicine-related issues were cared for by medicine hospitalists on HMHS. Methods: Criteria were established based on level of acuity and reason for admission to HMHS, which was comprised of a hospitalist attending and nurse practitioner. New admissions to HMHS were evaluated by the primary hematology malignancy service team as consultants and remained involved in patient care as deemed appropriate. Oncology attendings continued to care for patients on the primary leukemia, lymphoma, and myeloma services. We conducted a retrospective analysis from 6/28/21 through 6/30/22 excluding 1/2/22 to 2/6/22 when HMHS was paused due to the COVID Omicron surge. We compared length of stay (LOS), discharge before noon (DBN), and 30-day readmission rates of patients admitted to the HMHS service and those admitted to the primary services to assess for differences in outcomes. Results: There were a total of 95 (12%) admissions to HMHS and 669 (88%) to the primary services; 35.6% patients were white, 21.7% Black, and 10.3% Asian and 26.3% patients identified as Hispanic. The average age was 61.6 years. The average LOS in days was 9±9.09, 16.03±14.96, 11.41±14.88, and 12.68±11.40 (p = 0.005) for patients admitted to HMHS, leukemia, lymphoma and myeloma services, respectively. DBN on HMHS (6%) was similar to the leukemia service (6%) and improved compared to the lymphoma service (11%) and myeloma service (7%); p = 0.66. The 30-day readmission rate was also improved on HMHS (12%) compared to leukemia (21%), lymphoma (21%), and myeloma (18%); p=0.25. Conclusions: The development and implementation of a medicine hospitalist-driven hematology malignancy service significantly improved LOS without a negative impact on 30-day readmission rates when compared to a primary hematology malignancy service model. The addition of medicine hospitalists to the inpatient care of patients with hematologic malignancies demonstrates improvement in healthcare utilization. This is an important area for future evaluation to determine the most appropriate patients to admit to these services and assess other important outcomes.