No abstract

Synthesis of 3-Acetoxyazetidin-2-ones and 3-Hydroxyazetidin-2-ones with Antifungal and Antibacterial Activity.-The preparation and biological activity of a series of title compounds (III), (IV) and related compounds are investigated. Of particular interest are the title compounds (X) containing a free carboxylic acid group on the N-1 aryl ring. The novel bicyclic structure (XII) is also synthesized. Azetidinones (X) show moderate antibacterial activity. A number of monocyclic and bicyclic β-lactam derivatives display useful antifungal activity against a number of pathogenic fungi, cf. ( IVa), (IIIb), (VI), (Xa), and (XIII). -(WALSH, O. M.; MEEGAN, M. J.; PRENDERGAST, R. M.; NAKIB, T. AL.; Eur.

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ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.