The purpose of the research was to make a comparative study of the use of enzymatic probiotics in the feeding of young cattle Black-and-White breed and to determine their effect on growth, development and metabolic processes. Under the conditions of the Amur region the use of enzymatic probiotics in the feeding of young cattle has been justified in two scientific and economic experiments. In physiological experiments the digestibility of nutrients in rations has been determined; the balance of nitrogen, calcium and phosphorus has been studied. As a result of the first scientific and economic experiment, a comparative study of the feeding of enzymatic probiotics Cellobacterin and Vitacell to calves has been carried out. It has been found that the inclusion of the enzymatic probiotic Vitacell in the rations of calves had a better effect on growth, digestibility and balance of nutrients as well as improved hematological parameters, bringing them to the physiological norms. In the second experiment the effect of the enzymatic probiotics Vitacell and Promilk on the dynamics of the live weight of young cattle, their growth, development and metabolic processes has been studied. It has been found that the enzymatic probiotic Vitacell had a better effect on growth, digestibility and nutrient balance compared to the probiotic Promilk. Thus, physiological, biochemical, zootechnical and economic research methods proved the feasibility of using probiotics in the rations of calves of Black-and-White breed, but the best results were obtained when using the probiotic Vitacell. The data of the production inspection confirmed the results obtained in scientific and economic experiments.