Currently, little is known about the sensitization profile of children with asthma, allergic rhinitis (AR) and comorbid asthma in Ukraine. Aim. To study the sensitization profile in children with allergic respiratory diseases. Material and methods. Ninety-three children aged 5-17 years with allergic respiratory diseases were examined, including: 51 children with AR (1st group), 31 children with AR combined with asthma (2nd group) and 11 children with isolated asthma (3rd group). All children underwent multicomponent molecular diagnostics in the form of a multiplex test ALEX. Results. In monosensitized (17.2 %) and polysensitized (82.8 %) children with isolated asthma, with isolated AR and AR combined with asthma, sensitization to Fel d 1 was most common. Monosensitization to the ragweed molecule (Amb a 1) is characteristic only for children with AR, AR combined with asthma; to the cat molecule Fel d 1-for children with all allergic respiratory diseases. In monosensitized children with isolated AR, sensitization occurs only to the mold molecules Alt a 1, the fenugreek Lol p 1, timothy-grass (Phl p 1, Phl p 2, Phl p 5.0101, Phl p 6), in children with AR combined with asthma-to mites household dust (Der f 1, Der p 1), in children with isolated asthma-to the dog's epidermal allergen (Can f 1). In polysensitized children with respiratory allergy, the most common molecules to which sensitization is detected are Fel d 1, Bet v 1, Lol p 1, Phl p 1, Amb a 1 and Alt a 1.Conclusions.Children with allergic respiratory diseases exhibit different sensitization profiles. Sensitization to only one group of allergens was significantly more common in children with isolated asthma than in children with isolated AR and AR combined with asthma. Sensitization to Fel d 1 looks like a marker of respiratory allergy.

На допомогу педіатру / To Help the Pediatrician Opportunities of prevention of asthma exacerbation induced by respiratory infection in children using bacterial lysates Abstract. The infectious factor is known to play an important role not only as a trigger for asthma exacerbation, but also an essential factor for the formation of the disease. Children with asthma are 6.2 times more likely to have acute respiratory diseases than healthy children. This is due to altered barrier function of the respiratory epithelium and immune antiviral responses. Viruses dominate in the etiologi-cal structure of infectious-dependent exacerbations of asthma. The preclinical and clinical studies have shown the effectiveness of an immunomodulatory strategy for the prevention of recurrent respiratory infections in children with asthma using bacterial mechanical lysates.