The research results that presented in the article are focused on decreasing the intensity of pressure pulsations in the flowing part of centrifugal pumps. The aim of the work is researching influence of changes in construction and/or operating pump parameters on pressure pulsations amplitude. Basing on the research results, were determined the main sources of pressure pulsations in the flowing part of the spiral centrifugal pumps and the reasons of increasing their amplitude during pump operation mode at supply 0.3Qopt…0.7Qopt. The article presents information about dependencies of pump head and pressure pulsations amplitude on construction and operating pump parameters, such as: number of blades (z), blade width at the impeller outlet (b2), ratio of volute initial diameter to impeller outer diameter (D3/D2), angle of output edge inclination (φ), rotor rotation frequency (n) and blades position of impeller halves in relative to each other (shift step - ψ).