Growing increase of beauty salons and exposure to associated chemical substances present serious concern of chemical hazards and health problems. This study assessed indoor air quality (IAQ) of selected beauty salons in commercial and residential areas of Camp settlement in Abeokuta, Ogun State, Nigeria using Aeroqual GasSensing Monitor and WindMate® Weather Station. Human thermal sensation (HTS) was computed using Predicted Mean Vote (PMV) and Predicted Percentage of Dissatisfied (PPD) Indices. Data collected were subjected to descriptive and inferential statistics. Findings showed TVOC exceeded permissible exposure limit (0.2 mg/m3) in all salons and critical safe level (2500 ppm) for CO2 was exceeded in one-third. Exceedance was observed in less than one-third of salons for P.M2.5 and P.M10, due to varying activities taking place per time, and location differences. Where detected, H2S was below permissible limit (1.4 mg/m3). HTS was above the acceptable thermal comfort levels (PMV: ±0.5; PPD: <10%) in all salons. Generally, the IAQ indicates prevalence of inadequate ventilation, and portends increased exposure risk to hazardous chemical substances associated with salon activities. Therefore, formulation of policy, stipulating minimum operating standards and enforcement, alongside enlightenment campaign are necessary to promote human safety and prevent escalation of chemical related hazards in salons.