This study was conducted to investigate the challenges of students for the school of special needs in Kwara State. The descriptive survey research design was used by the researchers for the study.The purposive and simple random techniques were used in selecting 200 special needs students in the school. The questionnaire titled "Challenges of the Students in the School For Special Needs Questionnaire" (CSSSNQ) was administered by the researchers with the help of trained assistance to the respondents in order to elicit information from the sampled respondents. The items of the questionnaire were content validated and test re-test method was used to determine the reliability coefficient of 0.79. The major challenge of these students was their difficulty to relate unimpaired persons. Percentages were used to present the demographic data, while t-test and Analysis of Variance were used to test the four generated hypotheses. There were no significant differences found in the challenges of students of special needs school in Kwara State on the basis of gender, age, religious affiliation and their type of disability. Based on the findings of this study, it was recommended that alternative educational activities should be provided for these exceptional children. Also, the counselors can give social support to these children through counseling.