Relevance. The current period of Ukraine development is characterized by a number of socially conditioned stressors, which result in a significant increase in the number of cases of short-term, and most often, long-term stress. In particular, the duration of verbal and non-verbal communication with patients, their relatives, junior nurses (nurses, paramedics, midwives) is longer than in doctors, thus the psychological stress, which is also associated with maintaining their physical health, is much greater. The consequence of this is professional exhaustion, development of psychosomatic pathology, change of place of work. Objective of the work was to compile and propose a program of medical and psychological support for the process of medical college students adaptation to primary positions in treatment and prevention facilities. Methods. Students of the Kharkiv Regional Medical College and the Dnipro Basic Medical College took part in the study. The experimental group consisted of students in the number of 100 people aged 17.5±1.5 years. The control group (n=45) consisted of individuals 16.5±2.5. The research was conducted without gender. To assess the tasks Author's questionnaires were used: "Means of adaptation of students to study in a medical university of I-III levels of accreditation", and individually - typological questionnaire LM Sobchik. The data validity test for the Individual Typological Questionnaire was conducted to determine the validity and reliability of the answers in the categories "False" and "Aggravation". Statistical methods were used: middle and outward correlation analysis according to the criteria of Spirman and Pirson, Student's criterion. Results. The importance of medical and psychological support of the process of adaptation of junior medical specialists was studied, an original program was developed, which is an integrated structural procedural model of adaptation of medical college students to primary positions. After the introduction of the correctional program for working with students, the average level of student motivation increased by 17%, which was confirmed by the data of statistical analysis before and after the experiment. The results were also obtained: the average level of students' adaptive capabilities increased by 2 times.   Conclusions. The program introduced into the educational process will allow for a short period of time to adapt them to work in primary positions, form the need for continuous education and adherence to the principles of a healthy lifestyle. It will allow you to consolidate a positive coping strategy not only in a work environment, but also in everyday life.