Renal replacement dialysis therapy and kidney transplantation are considered complementary therapies for endstage chronic kidney disease. Even after successful kidney transplantation, no normalization of mineral-bone disorders occurs and hyperparathyroidism persists with the development of tertiary hyperparathyroidism with hypercalcemia and hypophosphatemia. The presented case demonstrates the difficulties of management and the need for timely diagnosis of mineral-bone disorders in chronic kidney disease and their complications. It is also an example of a relatively rare transition of secondary hyperparathyroidism, successfully treated before a kidney transplant, to tertiary hyperparathyroidism after allotransplantation, which served as an indication for parathyroidectomy.
Представлены данные о влиянии HCV-инфекции на развитие сахарного диабета. Показано, что HCV-инфекция вызывает поражение поджелудочной железы в виде инсулита, лимфоидной инфильтрации с последующей деструкцией островков Лангерганса. HCV оказывает повреждающее действие на мембраны β-клеток, приводит к их деструкции и изменению антигенных свойств, осуществляет запуск аутоиммунных реакций, вызывая повреждение β-клеток, развитие инсулиновой недостаточности и сахарного диабета 1-го типа.
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