Livestock breeding has been one of the main branches of animal husbandry in Ukraine including Slobozhanshchina (east of Ukraine). Breeding of small horned animals is the most important component of cattle breeding as the above category of ruminant animals is less whimsical to feeding and maintenance conditions. The worsening of the above conditions leads to the decrease in the animal productivity, their body resistance and the state of their immune system and it leads to re-infestation of the animals by helminths, eimeria and other zooparasites that periodically occurred on the objects of our research. Economical loss from some zooparasites and their associations in the above category of farm animals is connected with the improper feeding, decrease in the young animal preservation, retardation of their growth and development as well as with the disturbances of the reproductive function in the animals of the older age, the decrease in the quality and quantity of products and the increase in the forage cost. The publications made by the staff of the parasitology department of Kharkiv State Zooveterinary Academy and the results of the last coproscopic investigation of the animals that was carried out in autumn 2017 proved that the farm of small horned animals in the Training and Practical Complex of plant and animal husbandry in Kharkiv State Zooveterinary Academy (TPC KhSZVA) had been periodically unfavorable and there were outbreaks of invasive diseases connected with the regular breaking of the animal management, improper keeping and feeding conditions, breaking of veterinary and sanitary requirements. The research was planned and conducted in connection with the detection of zooparasite associations of different combinations in the sheep and with the appearance of veterinary preparations in the market macrolidic drug – «Ivermecvet 1 %». The aim of the investigation was to analyze the epizootic situation on the above farm in TPC KhSZVA, to practice coproscopic diagnosis of trichurosis in sheep and to develop more effective anthelminthic drug to control the above association of zooparasites and to work out more effective health measures for the above unfavorable farm and with the help of the publication we would like to share our experience to the owners of other unfavorable farms in the eastern part of Ukraine. Materials and methods. Fifty five unfavorable sheep of Precos breed from the collection herd of TPC KhSZVA were taken for the investigation. The standardized methods of coproscopy – flotation by Fulleborn and sedimentation were used for the laboratory diagnosis. By the results of the study it has been found out that the sheep in TPC KhSZVA at the beginning of the stall period of maintenance were unfavorable as for trichurosis (EI=59,3 %), strongylatosis of the digestive tract (79,6 %) and eimeriosis (57,4 %). The main pathogenic factor was trichurosis invasion that coursed simultaneously of rumen- and- intestinal strongilatosis and eimeriosis invasion. The above invasions were caused by of two species – Trichuris skrjabini and Trichuris ovis, the latter ones prevailed (1:9). Three kind of protozoa were detected in the composition of eimeriosis association – Eimeria ninaekohlyakimovae, Eimeria arloingi and Eimeria faurei. Eimeria ninaekohlyakimovae prevailed among them. 79,6 % of sheep were invaded by strongylates – parasites of the digestive tract, nematodiruses prevailed (69,8 %). The representatives of the family Strogylidae (esophagostomes) and numerous representatives of the family Trichostrongylidae prevailed in the composition of the detected strongylates. As the rate of the invasion by strongylates was comparatively low and in the form of parasite-bearing (65,1 %) we think that their role in the pathogenesis of zooparasitocenosis was a secondary one. Three and four-componet associations prevailed in the given zooparasitocenosis. It has been determined that classical flotation method by Fulleborn for the laboratory diagnosis of trichurosis in sheep is of no value but sedimentation method allowed us to diagnose the disease and to monitor the course of the invasive process as well as to determine the curative efficiency of the anthelminthic drugs used by us. «Ivermecvet 1 %» when injected subcutaneously at the dose of 0,5 ml per 25 kg of weight to the sheep having trichurosis and strongylatosis of the digestive tract was of 100 % efficiency and the above drug was recommended to treat animals of the above unfavorable farm. Key words: sheep, trichurosis, strongylatoses of digesative tract, eimeriosis, extensiveness and intensity, «Ivermecvet 1 %», «Levavet 10 %», «Diacox», extenseffectiveness and intenseffectiveness of anthelmintics.

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На збереженість поголів’я в популяціях диких птахів у природних умовах та умовах антропозооценозів впливає їх захворюваність на різні недуги, особливо небезпечними з них є заразні, серед яких важливе місце посідають зоопаразитози. Метою досліджень було встановити поширення основних збудників ендопаразитарних хвороб серед різних видів диких птахів. Епізоотичний моніторинг інвазійних хвороб серед диких птахів (n=38) у передмісті Харкова проводили у червні 2021 року під час карантинування їх у приватному притулку. Дослідження проб посліду проводили за стандартизованим флотаційним методом. З 38-ми проб від 11-ти видів диких птахів у 29 (76,3 %) виявлено ендопаразитарні захворювання. Ураженість сизих голубів, лебедів-шипунів, крижня звичайного, снігура звичайного, сорок звичайних і граків сягала 100 %. Ураженість круків звичайних та мартинів становила 50 та 25 % відповідно. Натомість, хижі види птахів виявилися вільними від зоопаразитів. З 11-ти сизих голубів, у 4-х встановлена еймеріозна моноінвазія, а у 7-ми – змішані інвазії, що складалися з еймерій, аскаридій, стронгілід травного каналу та капіляріїд, інтенсивність яких коливалася від 5,33±0,88 до 230,55±40,55 екз. овоскопічних елементів у 1 г посліду. У лебедів-шипунів встановлено змішані інвазії що складалися з еймерій, стронгілід травного каналу та капіляріїд за інтенсивності інвазії – 9,33±2,40, 5,00±0,58 та 4,00±1,00 екз. овоскопічних елементів у 1 г посліду відповідно. З 5-ти сорок звичайних у 2-х зареєстровано моноінвазії, а у 3-х – змішані інвазії що складалися з цестод, стронгілід і капіляріїд за інтенсивності інвазії 3,67±0,88, 4,33±0,67 і 7,75±1,55 екз. овоскопічних елементів у 1 г посліду відповідно. У граків переважали моноінвазії, спричинені збудниками цестодозів, стронгілідозів та капіляріїдами. У крижня звичайного діагностовано змішану еймеріозно-стронгілідозу інвазію. У круків і снігура звичайних та мартина діагностовано еймеріозну та капіляріїдозну моноінвазії відповідно. З-поміж інвазованих птахів у 48,3 % встановлено моноінвазії, викликані еймеріями, цестодами або капіляріїдами. Мікстінвазії зафіксовано у 51,7 % птахів, що складалися з 2-компонентних (34,5 % від загальної кількості хворої птиці) та 3-х і 4-х компонентних асоціацій паразитів (17,2 % від загальної кількості хворої птиці). Отримані дані мають важливе теоретичне та практичне значення, оскільки розширюють вже наявні відомості щодо поширення ендопаразитозів диких видів птахів на території різних природно-кліматичних регіонів України.

Laboratory diagnostics for any animal pathology refers to special research methods and helps not only in establishing the final diagnosis, but also in expanding data on the course of primary pathology and determining secondary complications based on changes in blood parameters. For this purpose, a clinical study of the blood of dogs with varying degrees of intensity of dirofilariasis invasion was carried out. It was found that the number of erythrocytes decreased in animals of the experimental groups, depending on the intensity of invasion. Severe erythropenia was found in the group of animals with the highest degree of invasion intensity (2.04±0.50 1012/l (p<0.001). It increased with an increasing in the degree of invasion and ESR up to 40.28±12.67 mm/h (p<0.05) and 62.50±14.16 mm/h (p<0.01). Thrombocyto-penia at 199.13±55.31 109/l was found in dogs in the group with the highest degree of invasion. Oligochromemia in animals also depended on the intensity of invasion and was 94.44±12.30 g/l (p<0.05) and 52.00±12.69 g/l (p<0.001). In dogs with the highest number of dirofilaria larvae, the hematocrit was 19.75±6.34 % (p<0.01) and leukocytosis developed (20.53±8.91 109/l). By calculating the leukocyte count in dogs with the highest degree of dirofilariasis invasion, a significant increase in the number of segmented neu-trophils was found to 86.00±10.43 % (p<0.1), eosinophils up to 27.88±5.54 % (p<0.001), basophils up to 1.75±1.39 % (p<0.001), appeared in blood of sick animals young neutro-phils (0.50±1.07 %, p<0.001). The established changes in hematological parameters are associated with the development of hemolytic anemia during invasion and the presence of latent bleeding associated with the destruction of the vascular wall by dirofilariae. The relative leukocytosis, which were diagnosed in sick dogs, is associated with the presence of nematodes and the development of inflammatory processes at the sites of localization and migration of dirofilaria. It is possible that leukocytosis and a shift of the leukocyte formula to the left are associated with intoxication of the body. Key words: dogs, heartworm disease, Dirofilaria im-mitis, blood, erythrocytes, leukocytes, leukocyte formula, hemoglobin, hematocrit, erythrocyte sedimentation rate.

The rabbit breeding industry in Ukraine is an important element of animal husbandry, most of the rabbits are in private households. In the absence of systematic veterinary care, accurate postmortem diagnosis of the causes of death of rabbits in households is important. Rabbit eimeriosis is widespread in Ukraine and with mixed intestinal and hepatic forms of eimeriosis against the background of unsatisfactory feeding and maintenance in young rabbits can cause death. Viral hemorrhagic disease of rabbits is also common in Ukraine and causes the death of rabbits of all ages. The aim was to study the pathomorphological changes in eimeria and viral hemorrhagic disease of rabbits and the use of other methods to confirm the diagnosis. The article presents the results of pathological, coprological and microbiological diagnosis of rabbit eimeriosis. Polymerase chain reaction was used to confirm the diagnosis of viral hemorrhagic disease of rabbits with the simultaneous establishment of the genotype of the pathogen. The effectiveness of the use of additional methods of postmortem diagnosis of eimeria (coprological, microscopic) and viral hemorrhagic disease of rabbits (polymerase chain reaction) was established. In rabbits that died from rabbit hemorrhagic disease the infection was caused by the virus of the first type. Key words: pathological and anatomical diagnosis, coproscopy, PCR, liver damage.